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EUROPOL

Financiado

EUROPOL

NMR and MRI play unique roles in contemporary Science, from Physics, Chemistry and Biology, to clinical research and diagnosis. Despite its irreplaceable role, further progress in NMR and MRI is hampered by sensitivities that are... ver más

31/08/2019

UoB

4M€

Presupuesto del proyecto: 4M€

Líder del proyecto

THE UNIVERSITY OF BIRMINGHAM No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 17 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2019-08-31

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

MSCA-ITN-2014-ETN: Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN)

I+D

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17 Participantes

UoB

546.58K€ | Lider

CUATRECASAS, GONCALVES PEREI...

799.65K€ | Participante

GUF

498.43K€ | Participante

TECHNICAL UNIVERSITY OF DENM...

290.08K€ | Participante

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Duración del proyecto: 56 meses Fecha Inicio: 2014-12-16
Fecha Fin: 2019-08-31

Líder del proyecto

THE UNIVERSITY OF BIRMINGHAM

TRL 4-5

Presupuesto del proyecto 4M€

Descripción del proyecto NMR and MRI play unique roles in contemporary Science, from Physics, Chemistry and Biology, to clinical research and diagnosis. Despite its irreplaceable role, further progress in NMR and MRI is hampered by sensitivities that are much lower than those of alternatives such as mass-spec, or PET. The prospects of solving this problem by bigger machines are uncertain and of poor return, given the high maturity already achieved by NMR/MRI. This ETN challenges this status from an untapped perspective, combining NMR/MRI with nuclear hyperpolarization eliciting signals that surpass those currently available by up to 50,000x. Focus is placed on two particular approaches, dynamic nuclear polarization and para-hydrogen-driven polarization, exhibiting the highest potential for biophysical, metabolomic, pre-clinical and clinical research. To maximize these supersignals we assembled leading experts in the physics and engineering of magnetic resonance, in the synthetic chemistry essential for the success of these methods, in the uses of NMR to structural/cell biology, and in preclinical and clinical MRI applications. Guiding this assembling is the conception that only by teaming together key areas of expertise, can hyperpolarisation’s promises be realized. In addition to fostering synergies among experts from academia and industry, EUROPOL will provide frontier training for ESRs in all the topics underlying the advancement of MR. This will include advanced physics, new instruments and forms of exploiting NMR/MRI’s hyperpolarisation, biophysical NMR, screening of healthy and diseased metabolomes, expanded portfolios of substrates to be targeted by in vivo MR, ancillary in cell and system biology explorations clarifying the nature of the metabolic phenomena, and in vivo hyperpolarisation strategies in MRI. This ETN is unparalleled in scope, breadth and potential for synergies.

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