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EndoConnect

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EU Training Network in understanding the molecular regulation and the role of en...

EU Training Network in understanding the molecular regulation and the role of endo lysosomal processes in cardio metabolic diseases The endo-lysosomal system is essential to acquire lipids and nutrients according to the need of the cell and, subsequently, to maintain metabolic homeostasis. The strong connection between the endo-lysosomal system and metabolism... ver más

31/03/2025

UNIVERSITAIR MEDIS...

4M€

Presupuesto del proyecto: 4M€

Líder del proyecto

ACADEMISCH ZIEKENHUIS GRONINGEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 12 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-09-03

MSCA-ITN-2020: Innovative Training Networks

I+D

Cerrada hace 5 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

12 Participantes

UNIVERSITAIR MEDISCH CENTRUM...

531.24K€ | Lider

UNIVERSITY OF BRISTOL

606.35K€ | Participante

265.62K€ | Participante

HELSINGIN YLIOPISTO

280.81K€ | Participante

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Duración del proyecto: 54 meses Fecha Inicio: 2020-09-03
Fecha Fin: 2025-03-31

Líder del proyecto

ACADEMISCH ZIEKENHUIS GRONINGEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 4M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The endo-lysosomal system is essential to acquire lipids and nutrients according to the need of the cell and, subsequently, to maintain metabolic homeostasis. The strong connection between the endo-lysosomal system and metabolism is reflected in the observations that defects in this system are correlated with cardio-metabolic disorders, such as cardiovascular disease, type 2 diabetes and non-alcoholic fatty liver disease. The molecular mechanisms that interconnect the endo-lysosomal system with metabolism are, however, poorly understood. This can be largely explained by the fact that (1) endo-lysosomal and metabolic research are carried out independent of each other and (2) the number of model systems to study endo-lysosomal processes at an organismal and clinical level are limited. It is the ambition of EndoConnect to change this by bringing top scientists and industrial partners together to train early stage researchers in interdisciplinary research, with the focus on translating key findings from cellular and animal models to patients with cardio-metabolic diseases. It is our mission to: (1) understand the molecular organization and regulation of endo-lysosomal processes, (2) elucidate how metabolism and endo-lysosomal processes are intertwined, (3) understand how defects in the endo-lysosomal system contribute to the development of cardio-metabolic diseases and, finally, (4) how the endo-lysosomal system contributes to the efficiency of therapeutics. EndoConnect will provide an international training program for early stage researchers to acquire knowledge and state-of-the-art scientific, technical, and transferable skills to connect molecular and cell biology research with physiology and biomedical research towards translation. We expect that EndoConnect will increase our understanding of the molecular interrelation of the endo-lysosomal system with cardio-metabolic diseases, which will pave the road for novel diagnostics and therapeutics.

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