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NOVOFLAT

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Escaping from Flatland by de novo Catalytic Decarboxylation Techniques

Although cross-coupling reactions have become one of the pillars of modern chemical synthesis, the ability to forge sp3–sp3 bonds with improved flexibility, practicality, predictable site-selectivity, preparative utility, stereoco... see more

30/04/2026

FUNDACIO INSTITUT...

3M€

Project Budget: 3M€

Project leader

FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMI... Otra investigación y desarrollo experimental en ciencias naturales y técnicas asociacion

TRL 4-5 | 100K€

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo H2020 notifico la concesión del proyecto The day 2020-05-04

ERC-2019-ADG: ERC Advanced Grant Scope:Objectives

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Cerrada does 5 years

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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2 Participantes

FUNDACIO INSTITUT CATALA D'I...

2.50M€ | Leader

BAIN EXTREMADURA U

284.37K€ | participant

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Project duration: 71 months Date Start: 2020-05-04
End date: 2026-04-30

Project leader

FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMI... Otra investigación y desarrollo experimental en ciencias naturales y técnicas asociacion

TRL 4-5 | 100K€

Project Budget 3M€

participation deadline Sin fecha límite de participación.

Project description Although cross-coupling reactions have become one of the pillars of modern chemical synthesis, the ability to forge sp3–sp3 bonds with improved flexibility, practicality, predictable site-selectivity, preparative utility, stereocontrol and with nearly zero-generation of waste has eluded chemists for decades, remaining a major challenge and an uncharted cartography in catalytic endeavours. The successful realization of this goal will represent a paradigm shift from the standard logic of organic synthesis in both basic and applied research, as increasing the number of sp3-hybridized carbon atoms has become a necessary goal in the drug discovery pipeline. NOVOFLAT offers a pioneering approach for forging sp3–sp3 linkages via a triple catalytic cascade that enables an unprecedented intramolecular decarboxylation of simple and available carboxylic acid esters with CO2 as the sole byproduct. As ester derivatives simply derive from naturally-occurring carboxylic acids and alcohols, this proposal will allow to rapidly access sp3–sp3 linkages with different electronic and steric requirements, thus providing an invaluable opportunity to streamline the discovery of important architectures with applications across the molecular sciences. Preliminary results demonstrate the feasibility to provide a la carte predictable tool that chemists could use to control the site where the sp3–sp3 bond-formation takes place in both aliphatic and cyclic frameworks, even at remote sp3 sites. In addition, our general principle offers an unrecognized opportunity to simultaneously construct sp3–sp3 linkages and control the stereochemistry at remote sp3 sites. In this manner, NOVOFLAT will not only provide new dogmas in retrosynthetic analysis by fundamentally altering the way sp3–sp3 bonds are made, but also open new vistas in chain-walking reactions, as the incorporation of chirality throughout the alkyl side-chain constitutes terra incognita in these technologies.

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