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EPIGAM2

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Epigenetics and chromatin dynamics in gametes using yeast spores and advanced...

Epigenetics and chromatin dynamics in gametes using yeast spores and advanced proteomics The field of epigenetics has been developing exponentially over the last decade. However, the organization of chromatin in gametes is still poorly understood. The role of this organization in fertilization and early embryonic deve... ver más

29/02/2016

CEA

100K€

Presupuesto del proyecto: 100K€

Líder del proyecto

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2016-02-29 No tenemos la información de la convocatoria

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CEA

0.00€ | Lider

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Líder del proyecto

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 100K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The field of epigenetics has been developing exponentially over the last decade. However, the organization of chromatin in gametes is still poorly understood. The role of this organization in fertilization and early embryonic development is largely unknown. For many years, I have been exploring different aspects of chromatin organization and dynamics during male gamete differentiation. The study of gametogenesis has proven to be technically challenging. My post-doctorate work, realized in the USA, demonstrated that a simple model, yeast sporulation, shares functional similarities with mammalian spermatogenesis. Taking advantage of this observation, I propose to deploy a new research program, EPIGAM2, using yeast sporulation as a powerful model for mammalian spermatogenesis. EPIGAM2 will be hosted by the group Exploring the Dynamics of Proteomes, directed by Jérôme Garin (Grenoble, France). The partnership between the candidate and the host laboratory has long-term interests, reinforcing cooperation between fundamental research and the development of new methodologies in proteomics. Indeed, EPIGAM2 combines multi-dimensional approaches using genetic, biochemical, and proteomic techniques. Project management has been carefully planned, and tasks, risk analyses, and milestones are presented. Support from this Marie Curie Action is vital for the launch of this research program, allowing the complete reintegration of the candidate and adequate development of his research program. To conclude, EPIGAM2 research program is based on a unique combination of (i) an innovative biological question, with potential implications for fertility care, cancer biology, and regenerative medicine, (ii) an original biological model, yeast spores, validated by several high profile publications, (iii) the impact of the program on the career of the candidate, the scientific community and outreach activities.

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