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DNA-bots

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Enzyme powered DNA nanorobotic devices

WHY: Enzyme-powered nanorobotic devices are able to self-propel thanks to the conversion of a substrate into products, holding a great potential for biomedical applications. A step forward in the field would be the precise control... ver más

31/03/2021

UNITOV

183K€

Presupuesto del proyecto: 183K€

Líder del proyecto

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-03-31

MSCA-IF-2018: Individual Fellowships

I+D

Cerrada hace 6 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNITOV

183.47K€ | Lider

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Duración del proyecto: 24 meses Fecha Inicio: 2019-03-19
Fecha Fin: 2021-03-31

Líder del proyecto

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 183K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto WHY: Enzyme-powered nanorobotic devices are able to self-propel thanks to the conversion of a substrate into products, holding a great potential for biomedical applications. A step forward in the field would be the precise control and design over the structure and enzyme spatial configuration, as well as the integration of complex functions. WHAT: DNA-bots is an interdisciplinary approach in which enzyme-propulsion and DNA nanotechnology will be merged to develop a new class of biocompatible and biodegradable nanorobotic devices able to self-propel, sense and actuate in front of specific stimuli. To achieve this goal, I will undertake a high risk/high gain research approach at the forefront of nanotechnology. The leading idea is to design and fabricate DNA nanostructures which will be site-specifically functionalized with enzymes to generate self-propulsion. The enzyme-powered DNA nanorobots will be further engineered by integrating DNA nanoswitches able to sense and perform loading and release of cargoes upon specific stimuli. HOW: The challenge met by this Project is to provide a groundbreaking contribution to DNA nanotechnology and nanorobotics. To achieve these objectives, I will be trained at the Host group led by Prof. Francesco Ricci (University of Rome Tor Vergata, Italy), which is a young and dynamic team at the vanguard of the use of DNA nanotechnology for sensing and drug-delivery applications. The Fellowship will proceed through a well-defined set of research and training tasks, organized into four work packages. Thanks to this MSCA Fellowship, I will continue expanding my scientific knowledge and acquiring cutting-edge skills (in synthetic biology, DNA nanotechnology, and nanorobotics), which will significantly impact my career as a researcher and help me to strenghten my position as an independent and mature researcher.

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