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ENHANCE-SKIN

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Enzyme Immobilization for Enhanced Transdermal Penetration of Bioactive Compound...

Enzyme Immobilization for Enhanced Transdermal Penetration of Bioactive Compounds for Treating Skin Diseases The use of natural bioactive compounds (NBCs) in dermatological treatment is a promising healthcare frontier, however their effectiveness is hindered by limitations in skin penetration. Enhancing their delivery to target skin laye... ver más

30/09/2026

NATIONAL HELLENIC...

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ETHNIKO IDRYMA EREVNON No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-10-01

HORIZON-WIDERA-2023-TALENTS-02-01: ERA Fellowships Expected Outcome:This action builds on the MSCA Postdoctoral Fellowships 2023 action (HORIZON-MSCA-P...

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NATIONAL HELLENIC RESEARCH F...

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Duración del proyecto: 23 meses Fecha Inicio: 2024-10-01
Fecha Fin: 2026-09-30

Líder del proyecto

ETHNIKO IDRYMA EREVNON No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The use of natural bioactive compounds (NBCs) in dermatological treatment is a promising healthcare frontier, however their effectiveness is hindered by limitations in skin penetration. Enhancing their delivery to target skin layers or specific disease sites remains a significant challenge. Encapsulation of NBCs within nanodispersions (NDs) and their embedding in a biopolymer hydrogel matrix has demonstrated promising outcomes in terms of improving the delivery of NBCs through the skin. However, there's still a need for more significant enhancement in penetration, while the reasons behind this effect remain uncertain. This project aims to overcome these challenges through the immobilization of enzymes, like hyaluronidase, that breaks down hyaluronic acid (major skin component) within the biopolymer hydrogel matrix. By prioritizing enzyme immobilization as a catalyst for enhanced penetration, this project pushes the boundaries beyond traditional encapsulation methods. This project plans to extract bioactive compounds from natural sources and investigate effective biocompatible encapsulation methods. Additionally, it will assess the biopolymer hydrogel matrix where the developed NDs and enzymes will be incorporated and immobilized. The equilibrium of the immobilized enzyme will be carefully studied to achieve optimal association and dissociation, aiming to enhance transdermal delivery while maintaining skin health. Moreover, comprehensive bioavailability and cytotoxicity studies, as well as in vitro and ex vivo analyses for in depth characterization of the transdermal delivery of NBCs are planned. By merging biocatalysis and nanomaterials, this project offers a more effective alternative to conventional treatments, including skin cancer, minimizing the ecological impact.

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