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Enzymatic cascade biotransformations in digitally manufactured continuous-flow b...

Enzymatic cascade biotransformations in digitally manufactured continuous-flow bioreactors Within Industrial Biotechnology, applied biocatalysis is poised to transform drug discovery and development by pharmaceutical industry. Enzymes as catalysts, allow for synthetic chemists to generate molecular complexity avoiding c... ver más

15/01/2025

FUEUJI

165K€

Presupuesto del proyecto: 165K€

Líder del proyecto

UNIVERSITAT JAUME I DE CASTELLÓ No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 2

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-08-10

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021 ExpectedOutcome:

I+D

Cerrada hace 3 años

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1 Participantes

FUEUJI

165.31K€ | Lider

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Duración del proyecto: 29 meses Fecha Inicio: 2022-08-10
Fecha Fin: 2025-01-15

Líder del proyecto

UNIVERSITAT JAUME I DE CASTELLÓ No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 2

Presupuesto del proyecto 165K€

Descripción del proyecto Within Industrial Biotechnology, applied biocatalysis is poised to transform drug discovery and development by pharmaceutical industry. Enzymes as catalysts, allow for synthetic chemists to generate molecular complexity avoiding costly and time-consuming protection and deprotection steps. However, the high cost associated to their use, especially if a co-factor is required, the low substrate tolerance and productivity and the difficulties for scale-up, strongly limit the industrial uptake of these processes. The combination of enzyme immobilisation and continuous flow (CF), offers an opportunity to overcome these limitations. Enzymatic performance and recyclability can be dramatically improved by immobilisation and generic problems such as low productivity and substrate inhibition effect can be solved using CF. During the last years, enzymes have been most commonly immobilised in packed bed reactors. However, the very low flow rates required to achieve full conversion, decrease the mixing and make the system look closer to a batch reaction (with its generic problems). Here we aim to address these limitations through the design and manufacture of 3D Printed (3DP) reactors that combine optimised mixing at low flow rates, with tailored surface modification techniques with ionic liquids (ILs) for stable biocatalyst preparation and higher number of active sites. 3DP facilitates the generation of complex geometries in a variety of materials based on ILs, tailored to optimise enzyme stability. The aim of this proposal is to integrate chemical engineering (3DP continuous flow reactors) and biocatalysis (stable and recyclable immobilised enzymes) to develop more efficient biotransformations in flow, easy and effective immobilisation of enzymes and significantly promote sustainable development of IB. It will have a direct impact in the EU from an environmental, economic and social perspective, lowering drug prices, facilitating distributed production and reducing waste.

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