Innovating Works

EnterBio

Financiado
Enteric Bioelectronics for Sensing and Stimulating the CNS
Therapies for neurological disorders often involve deeply invasive brain operations or implants. A largely overlooked aspect of these conditions is the high comorbidity of GI-related disorders. Although the top-down relationship b... Therapies for neurological disorders often involve deeply invasive brain operations or implants. A largely overlooked aspect of these conditions is the high comorbidity of GI-related disorders. Although the top-down relationship between the brain and peripheral organs has dominated the field, it’s now clear that activity of peripheral organs, in particular GI innervation – the enteric nervous system (ENS) – not only influences brain activity, but also paces and regulates it. Indeed, recent studies have shown the bidirectional relationship between gut homeostasis and neurological function in disorders such as epilepsy, Alzheimer’s, and Parkinson’s. EnterBio will adapt bioelectronic tools developed over the past decades for application in the CNS for sensing and stimulating the ENS, and thereby sensing and stimulating the CNS. The team comprises world-leading expertise in organic and graphene bioelectronics, drug delivery, in vitro/animal models of neurodegenerative disorders, and molecular/ cellular physiology of the PNS. We propose to turn this expertise toward the ENS to develop a platform for elucidation, prediction, and control of CNS function. Objectives are to: – Develop bioelectronic sensors, stim. electrodes, and drug deliv. targeting ENS and adapted for implantation in the gut – Elucidate ENS control of CNS using high-res sensing signals in vivo – Demonstrate control & eventual therapy for CNS disorders without highly invasive implants EnterBio proposes to build on new, cutting-edge directions (organic/carbon-based bioelectronics and the gut-brain axis) to disrupt the field of CNS sensing/neuromodulation as technology to utilize ENS activity as an entry point to brain (dys)function is lacking. Entering the bio through the gut will be exactly this disruptor. EnterBio will achieve substantial improvements in relation to the barriers and obstacles of today’s sensing/neuromodulation technologies. ver más
29/02/2028
LIU
3M€
Duración del proyecto: 50 meses Fecha Inicio: 2023-12-18
Fecha Fin: 2028-02-29

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-12-18
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
HORIZON-EIC-2023-PATHFINDEROPEN-01-01: EIC Pathfinder Open
Cerrada hace 1 año
Presupuesto El presupuesto total del proyecto asciende a 3M€
Líder del proyecto
LINKOPINGS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5