Innovating Works

ProteoKnot

Financiado
Entangled tertiary folds
The most sophisticated functions of proteins emerge at the level of their tertiary structure and involve large amplitude conformational changes. In contrast, the functions of synthetic molecules are currently limited by our inabil... The most sophisticated functions of proteins emerge at the level of their tertiary structure and involve large amplitude conformational changes. In contrast, the functions of synthetic molecules are currently limited by our inability to control their structure beyond the level of static secondary structures. ProteoKnot seeks to address this limitation by introducing entanglements as a tool to control tertiary folding while maintaining the flexibility required to allow them to change conformation. The first objective of this project is to establish design principles to guide the construction of entangled tertiary folds. These principles will be tested with the assembly of multiply-stranded helices (WP1), entangled macromolecules (WP2) and polymers (WP3). The second objective is to introduce photoswitchable handles in these structures to enable remote control over their conformational states (WP4). Operating the transition from the traditional design of static secondary folds to the design of dynamic tertiary folds will unlock the possibility to engineer increasingly complex macromolecules with protein-like functions. These exquisite architectures feature tandem helical motifs and cavities, providing an avenue toward highly elaborated receptors and catalysts. To illustrate the great potential of entangled tertiary folds for future applications, our third objective will be to develop their use as multi-responsive switchable catalysts (WP5). ver más
31/05/2028
2M€
Duración del proyecto: 63 meses Fecha Inicio: 2023-02-25
Fecha Fin: 2028-05-31

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-02-25
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
Presupuesto El presupuesto total del proyecto asciende a 2M€
Líder del proyecto
JYVASKYLAN YLIOPISTO No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5