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NANOGLU

Financiado

Enlightening synaptic architecture nanoscale segregation of glutamate receptor...

Efficient neuronal communication lies at the heart of all cognitive functions, and synaptic dysfunction underlies mental disorders such as autism. However, although over the past decades many components of synapses have been chara... ver más

31/03/2022

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITEIT UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-03-31

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2016-STG: ERC Starting Grant

I+D

Cerrada hace 9 años

0% 100%

2 Participantes

1.50M€ | Lider

RADIACION Y MICROONDAS

240.80K€ | Participante

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Últimas noticias

25-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 52 concesiones

25-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 1 concesiones

25-11-2024: FUNDACION-EOI En las últimas 48 horas el Organismo FUNDACION EOI ha otorgado 6 concesiones

Duración del proyecto: 64 meses Fecha Inicio: 2016-11-30
Fecha Fin: 2022-03-31

Líder del proyecto

UNIVERSITEIT UTRECHT

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto Efficient neuronal communication lies at the heart of all cognitive functions, and synaptic dysfunction underlies mental disorders such as autism. However, although over the past decades many components of synapses have been characterized, it is unknown how these constituents are assembled within synapses, and how this organization contributes to synapse function. The overall aim of this proposal is to understand how excitatory synapses are built to efficiently control neuronal function. Specifically, I aim to reveal the molecular organization that controls glutamate receptor positioning. While AMPA-type glutamate receptors concentrate in nano-domains within the synaptic core that directly apposes the presynaptic release site, metabotropic glutamate receptors accumulate in a distinct perisynaptic domain considerably further from the release site. Despite that this organization critically controls synaptic transmission and plasticity, we know little about the mechanisms that underlie the spatial and temporal segregation of glutamate receptor subtypes into these distinct subsynaptic domains. To address this, I developed single-molecule imaging tools, a powerful dimerization system to control receptor positioning, and physiological read-outs of synapse function. In this proposal I will combine innovative experimental and computational approaches, integrating single-molecule imaging with optical and electrophysiological measurements of neuronal function to: 1) elucidate the organizational principles that underlie the nano-compartmentalization of glutamate receptors at synapses, and 2) understand how the spatial distribution of receptor subtypes contributes to neuronal functioning. This project will reveal how nanoscale synapse organization contributes to neuronal circuit function, and will help understand how synaptic disruption contributes to neurological disease mechanisms.

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