Engineering a living human Mini-heart and a swimming Bio-robot
Cardiovascular disease (CVD) is still the N1 cause of death worldwide despite the significant efforts of academia and pharmaceutical industry to understand the different underlying causes of CVD. They have been hampered by the lac...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
BioRobot-MiniHeart
Engineering a living human Mini-heart and a swimming Bio-rob...
4M€
Cerrado
3DVasCMD
Development of novel 3D vascularized cardiac models to inves...
1M€
Cerrado
LIFEVALVE
Living autologous heart valves for minimally invasive implan...
16M€
Cerrado
HybridHeart
Development of the first fully biocompatible soft actuated...
3M€
Cerrado
G-CYBERHEART
Computationally and experimentallY BioEngineeRing the next g...
1M€
Cerrado
BRAV3
Computational biomechanics and bioengineering 3D printing to...
8M€
Cerrado
Información proyecto BioRobot-MiniHeart
Duración del proyecto: 59 meses
Fecha Inicio: 2022-11-01
Fecha Fin: 2027-10-31
Líder del proyecto
UNIVERSITEIT TWENTE
No se ha especificado una descripción o un objeto social para esta compañía.
TRL
4-5
Presupuesto del proyecto
4M€
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
Cardiovascular disease (CVD) is still the N1 cause of death worldwide despite the significant efforts of academia and pharmaceutical industry to understand the different underlying causes of CVD. They have been hampered by the lack of proper human cardiac models as the animal models have different physiology and gene expression from the human situation and the flat cell culture in vitro models are not capable of producing pumping motion, which is the main function of the heart. Furthermore, pesticides toxicity and risk for human health are controlled at a European level through a well-developed regulatory network, however, cardiotoxicity is not described as a separate hazard class while it can have long-term cardiovascular complications. Here we propose to make better predicative in vitro cardiac models by making a vascularized beating mini-heart and a self-propulsion swimming bio-robot made by assembling human cardiac cells into 3D tissue structures using sacrificial molding and high-resolution 3D bio-printing. The mini-heart and the bio-robot will enable the scientific community to have a more realistic human cardiac model in vitro and a proper tool to assess the presence of cardiotoxicants in the environment. This work will be done in a consortium of four parties with the necessary expertise, ranging from heart development, human pluripotent stem cells, 3D bioprinting, tissue engineering and biosensing, to bring these engineered living tissues to reality.