Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

ProLiCell

Financiado

Cerrado

Engineered Protein Nanosheets at Liquid Liquid Interfaces for Stem Cell Expansio...

Engineered Protein Nanosheets at Liquid Liquid Interfaces for Stem Cell Expansion Sorting and Tissue Engineering A long standing dogma in the field of cell-based technologies is that bulk mechanical properties of solid substrates are essential to enable cell spreading, proliferation and fate decision. The use of solid materials to culture ad... ver más

31/08/2024

QMUL

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

QUEEN MARY UNIVERSITY OF LONDON No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-08-31

ERC-2017-COG: ERC Consolidator Grant

I+D

Cerrada hace 7 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

QMUL

2.00M€ | Lider

GENERAL OPTICA

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

BES-2010-035941 DINAMICA DE LAS PROTEINAS DE LA MATRIZ EN LA INTERFASE CELUL... 43K€ Cerrado

ProBioFac Protein Nanosheet Stabilised Emulsions for Next Generation B... 150K€ Cerrado

PID2019-106236GB-I00 POLIESTERES BIODEGRADABLES NANOSTRUCTURADOS Y NANOCOMPOSITES... 109K€ Cerrado

GRAPHITE4MED Aerographite as scaffold material for regenerative medicine 162K€ Cerrado

BioCHIPs BioCHIPS - Biofabricated microfluidcs CHIPS based on self as... Cerrado

SUPRAforORGANS Synthetic supramolecular polymers as artificial extracellula... 178K€ Cerrado

Duración del proyecto: 76 meses Fecha Inicio: 2018-04-27
Fecha Fin: 2024-08-31

Líder del proyecto

QUEEN MARY UNIVERSITY OF LONDON No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto A long standing dogma in the field of cell-based technologies is that bulk mechanical properties of solid substrates are essential to enable cell spreading, proliferation and fate decision. The use of solid materials to culture adherent cells constitutes an important hurdle for the scale up, automation and speed up of cell culture and recovery. Our recent results show that bulk solid substrates are not necessary to promote cell adhesion, growth and fate regulation as adherent stem cells spread and proliferate readily at the surface of ultra-soft materials, even liquids. In such cases, cell adhesion is enabled by the formation of a mechanically strong layer (nanosheet) of proteins at the interface between the oil (liquid substrate) and aqueous medium. This key discovery opens the door to the engineering of protein nanosheets enabling the use of liquid, free-flowing substrates sustaining cell adhesion, expansion, isolation and recovery. ProLiCell will design the biochemical and mechanical properties of extracellular matrix (ECM) protein nanosheets that can sustain the formation of adhesion protein complexes and support cell proliferation and culture on materials with very weak bulk mechanical properties (liquids). The engineered ECM nanosheets will be applied to: 1. the design of 3D bioreactors based on emulsions, for the culture of stem cells; 2. the formation of stem cell sheets at oil-water interfaces for tissue engineering; 3. the isolation and purification of stem cells using emulsions presenting antibody-adsorbed interfaces. ProLiCell will provide fundamental insights into ECM nanosheet design and advance our understanding of the mechanisms via which cells adhering to such interfaces sense and respond to nanoscale cues. Such fundamental understanding will enable liquid-liquid platforms to transform stem cell technologies by borrowing a wider range of processing and manufacturing concepts to the field of Chemical Engineering.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores