Innovating Works

E-CTRL

Financiado
Engineered control of cellular circuits
Protein signaling in cells is precisely coordinated in space and time. Molecular chemogenetics, optogenetics, and biosensors have generated a scientific revolution enabling the spatiotemporal codes of protein signaling in single c... Protein signaling in cells is precisely coordinated in space and time. Molecular chemogenetics, optogenetics, and biosensors have generated a scientific revolution enabling the spatiotemporal codes of protein signaling in single cells. However, it is a great challenge to study protein dynamics in a physiological multicellular environment due to the extensive variability in protein signaling within individual cells, as well as the sparsity of driver cells responsible for a specific physiological process. To build causal relationships between proteins and multi-cellular behavior, we will develop broadly applicable technologies by engineering proteins enabling the control of target proteins with light, exclusively in the relevant driver cell subpopulations. These approaches can be used in any biological field in which protein signaling is critical for multi-cellular behavior, but here we will focus on three different stages of a challenging neurobiology process. Upon sensory experience, for example, by learning a new task, only the subsets of neurons within a corresponding brain region switch to the active state. It is largely unknown how proteins that are activated in these sparsely activated neuronal circuits operate in space and time. Our technologies will enlighten the spatiotemporal dynamics of proteins in active neuron subpopulations responding to certain learning tasks in mice. Understanding such learning neuronal circuit responses at the molecular level will pave the way to develop new therapeutic approaches for brain disorders including epilepsy, depression, and autism spectrum disorders. ver más
30/04/2028
KI
1M€
Perfil tecnológico estimado
Duración del proyecto: 62 meses Fecha Inicio: 2023-02-01
Fecha Fin: 2028-04-30

Línea de financiación: concedida

El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-02-01
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
ERC-2022-STG: ERC STARTING GRANTS
Cerrada hace 2 años
Presupuesto El presupuesto total del proyecto asciende a 1M€
Líder del proyecto
KAROLINSKA INSTITUTET No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5