CapBed
Financiado
Engineered Capillary Beds for Successful Prevascularization of Tissue Engineerin...
Engineered Capillary Beds for Successful Prevascularization of Tissue Engineering Constructs
The demand for donated organs vastly outnumbers the supply, leading each year to the death of thousands of people and the suffering of millions more. Engineered tissues and organs following Tissue Engineering approaches are a poss...
The demand for donated organs vastly outnumbers the supply, leading each year to the death of thousands of people and the suffering of millions more. Engineered tissues and organs following Tissue Engineering approaches are a possible solution to this problem. However, a prevascularization solution to irrigate complex engineered tissues and assure their survival after transplantation is currently elusive. In the human body, complex organs and tissues irrigation is achieved by a network of blood vessels termed capillary bed which suggests such a structure is needed in engineered tissues. Previous approaches to engineer capillary beds reached different levels of success but none yielded a fully functional one due to the inability in simultaneously addressing key elements such as correct angiogenic cell populations, a suitable matrix and dynamic conditions that mimic blood flow.
CapBed aims at proposing a new technology to fabricate in vitro capillary beds that include a vascular axis that can be anastomosed with a patient circulation. Such capillary beds could be used as prime tools to prevascularize in vitro engineered tissues and provide fast perfusion of those after transplantation to a patient. Cutting edge techniques will be for the first time integrated in a disruptive approach to address the requirements listed above. Angiogenic cell sheets of human Adipose-derived Stromal Vascular fraction cells will provide the cell populations that integrate the capillaries and manage its intricate formation, as well as the collagen required to build the matrix that will hold the capillary beds. Innovative fabrication technologies such as 3D printing and laser photoablation will be used for the fabrication of the micropatterned matrix that will allow fluid flow through microfluidics. The resulting functional capillary beds can be used with virtually every tissue engineering strategy rendering the proposed strategy with massive economical, scientific and medical potential
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Duración del proyecto: 78 meses
Fecha Inicio: 2018-10-25
Fecha Fin: 2025-04-30
Fecha Fin: 2025-04-30
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2018-10-25
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-2018-STG:
ERC Starting Grant
Cerrada
hace 7 años
Presupuesto
El presupuesto total del proyecto asciende a
1M€
Líder del proyecto
UNIVERSIDADE DO MINHO
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
447.52K€ |
Participante