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e-MICROBe

Financiado

Energizing microbes with redox mediators for new bioproductions

In many bioprocesses a broad bioproduct portfolio can currently only be obtained when microorganisms can access oxygen as an electron acceptor. For numerous target substances, however, oxygen is detrimental to product stability an... ver más

31/08/2025

Leibniz-HKI LEIBNI...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

LEIBNIZINSTITUT FUR NATURSTOFFFORSCHUNG UND I... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-02-18

ERC-2019-COG: ERC Consolidator Grant

I+D

Cerrada hace 5 años

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2 Participantes

Leibniz-HKI LEIBNIZ INSTITUT...

2.00M€ | Lider

BIOTECHNOLOG INSTITUTE

118.20K€ | Participante

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Duración del proyecto: 66 meses Fecha Inicio: 2020-02-18
Fecha Fin: 2025-08-31

Líder del proyecto

LEIBNIZINSTITUT FUR NATURSTOFFFORSCHUNG UND I... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Descripción del proyecto In many bioprocesses a broad bioproduct portfolio can currently only be obtained when microorganisms can access oxygen as an electron acceptor. For numerous target substances, however, oxygen is detrimental to product stability and the bioprocess operation. The central aim of e-MICROBe is to innately couple microbial metabolism and electrochemistry via a self-secreted soluble electron mediator to achieve efficient oxygen independent energy metabolism and to directly steer and control metabolism and product formation. This will require creating entirely new physiological traits for production and utilization of redox mediators to generate cellular energy. Thereby, mediators can either act as electron discharge shuttle to enable electro-respiration at an anode or they are employed as inorganic energy donor to deliver electrons from a cathode into the metabolism. We will clarify the underlying reaction pathways in known environmental microorganisms and re-engineer the energy metabolism of common biotech hosts. Thereby, we will switch cellular energy generation from aerobic respiration to anaerobic anodic electro-respiration or from hydrogen consumption as autotrophic electron donor to cathodic electron consumption. The latter process will provide a mechanism to store electrical energy in microbial products. For a new level of in situ insight into microbial energy metabolism, a novel micro-scale bioelectrochemical reactor coupled to microscopic observation and high performance analysis will be developed. With this technique two fundamental concepts for future mediator-based bioprocesses will be evaluated: An all-in-one strategy where one cell is generating the mediators and the targeted product as well as a co-culture system, whereby one cell produces the mediators and a partner cell utilizes them for electro-respiration and product formation. This concept will lay the foundation for a plug-and-play exchange of biotech strains in a mediator-producing co-culture system.

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