Enabling advances in diagnosis, patient stratification and treatment for dilated...
Enabling advances in diagnosis, patient stratification and treatment for dilated cardiomyopathy patients and families.
Dilated Cardiomyopathy (DCM) is a heart muscle disorder characterised by thinning and stretching of the heart ventricles, making it harder for the heart to pump blood (systolic dysfunction). This disorder, with an estimated preval...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
CARDIOREPAIR
Comprehensive Analysis of RBM20-induced Dilated Cardiomyopat...
4M€
Cerrado
BIO2011-25369
BUSQUEDA RAPIDA Y RENTABLE DE CARDIOMIOPATIAS MEDIANTE ANALI...
145K€
Cerrado
PID2021-128698OB-I00
ESTUDIO AVANZADO DEL NICHO CARDIOVASCULAR ASOCIADO A LA POBL...
169K€
Cerrado
PTQ-11-05005
Optimización de un método de diagnóstico de riesgo genético,...
64K€
Cerrado
INDIVUHEART
Individualized early risk assessment for heart diseases
2M€
Cerrado
Información proyecto DCM-NEXT
Duración del proyecto: 51 meses
Fecha Inicio: 2023-06-20
Fecha Fin: 2027-09-30
Líder del proyecto
STICHTING AMSTERDAM UMC
No se ha especificado una descripción o un objeto social para esta compañía.
TRL
4-5
Presupuesto del proyecto
4M€
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
Dilated Cardiomyopathy (DCM) is a heart muscle disorder characterised by thinning and stretching of the heart ventricles, making it harder for the heart to pump blood (systolic dysfunction). This disorder, with an estimated prevalence of up to 1/250, predominantly affects younger adults. It is associated with significant morbidity and mortality, including heart failure and sudden cardiac death, with end-stage DCM being the leading indication for heart transplantation.
The current disease burden in DCM is largely attributable to two important gaps in scientific knowledge: Firstly, our understanding of the aetiology and genetic architecture of DCM remains limited, hindering the utility of genetic testing in clinical patient management. Secondly, there are limited therapeutic options for DCM patients. Existing therapies are generic and target symptoms. No curative treatments exist, apart from invasive heart transplantation and there are no approved therapies targeting underlying molecular disease mechanisms.
A fuller understanding of the genetic architecture of DCM and knowledge of the genes and genetic variants involved are critically needed to provide solutions for these unmet medical needs.
The DCM-NEXT consortium combines world-leading interdisciplinary expertise and resources of 8 investigators in the fields of DCM, deep clinical phenotyping, cardiogenomics, cardiac transcriptomics, artificial intelligence, in silico drug target discovery and functional studies. They will uniquely leverage their unparalleled cohort of 11,750 DCM probands and relatives with extensive clinical and omics data.
Through cutting-edge genomic and cardiac transcriptomic studies, the project aims to (1) revolutionise genetic testing and patient stratification for more precise prediction of disease onset, progression and risk of major adverse cardiac events; and (2) accelerate development of novel therapies by identifying and validating targets involved in pathogenesis of DCM.