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ENLIGHT

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Cerrado

ENable LIGHT and synthetic biology driven volumetric bioprinting of functional...

ENable LIGHT and synthetic biology driven volumetric bioprinting of functional human tissues With its ability to print living cells into shapes that resemble human organs, 3D bioprinting has risen exceptional hopes in the quest to produce lab-made human tissues for biomedical applications. However, today’s bioprinting has... ver más

30/04/2025

UMC UTRECHT

4M€

Presupuesto del proyecto: 4M€

Líder del proyecto

UNIVERSITAIR MEDISCH CENTRUM UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 9 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-01-22

FETOPEN-01-2018-2019-2020: FET-Open Challenging Current Thinki...

I+D

Cerrada hace 6 años

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

9 Participantes

UMC UTRECHT

1.01M€ | Lider

MEGADYNE RUBBER,

229.63K€ | Participante

EPFL

250.00K€ | Participante

FGB

40.00K€ | Participante

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Duración del proyecto: 51 meses Fecha Inicio: 2021-01-22
Fecha Fin: 2025-04-30

Líder del proyecto

UNIVERSITAIR MEDISCH CENTRUM UTRECHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 4M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto With its ability to print living cells into shapes that resemble human organs, 3D bioprinting has risen exceptional hopes in the quest to produce lab-made human tissues for biomedical applications. However, today’s bioprinting has no means to actively steer cell behaviour and morphogenesis, leaving yet unfulfilled the potential to fully capture organ functions. Challenging this current perspective, ENLIGHT merges synthetic biology, 3D printing, and photonics to develop a radically new technological concept termed optogenetic volumetric bioprinting. This ultra-fast technique uses visible light tomography to sculpt cells and biomaterials into multi-material, high-resolution, centimetre-scale living tissues within less than a minute. Through synthetic biology-inspired strategies, stem cells gain the ability to sense and respond to light patterns provided by the printer and differentiate into selected cell types, essentially permitting for the first time to 3D print cell functions. ENLIGHT targets two breakthroughs: the development of a volumetric bioprinter capable of optogenetic stimulation to instruct cell fate, and its application to build physiological-scale tissues and organoids that replicate human organ-level functionality. As proof-of-concept ENLIGHT will print vascularized endocrine pancreas models that exhibit native-like function. ENLIGHT will introduce a technology for bioprinting a new generation of reliable user-customizable in vitro models to study human biology and pathology. This is urgently needed to advance drug discovery, personalized medicine and to aid the transition to animal-free biomedical research. These results and the actions of industrial, academic and social science consortium partners, will lay the foundation to build market opportunities, leading research and innovation capacity across Europe. On the longer term, ENLIGHT envisions to offer new tools to solve donor organ shortage for transplantation and regenerative medicine.

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