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ExoDiagAI

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Cerrado

Empowering Personalized Therapeutics: Advancing 3D-Nano DLD Arrays and Raman Mic...

Empowering Personalized Therapeutics: Advancing 3D-Nano DLD Arrays and Raman Micro-Biochips for Precision Isolation, Segmentation, and Molecular Profiling of Exosomal Trop2 Biomarkers in TNB The ExoDiagAI project is at the forefront of addressing a critical challenge in modern healthcare—early diagnosis and effective management of breast cancer, particularly the aggressive and elusive triple-negative breast cancer (TN... ver más

14/07/2026

LEIBNIZINSTITUT FU...

190K€

Presupuesto del proyecto: 190K€

Líder del proyecto

LEIBNIZINSTITUT FUER PHOTONISCHE TECHNOLOGIEN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-05-14

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023 ExpectedOutcome:Project results are expected to contribute to the following outcomes:

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

LEIBNIZINSTITUT FUER PHOTONI...

189.69K€ | Lider

WMU

N.D. | Participante

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Duración del proyecto: 26 meses Fecha Inicio: 2024-05-14
Fecha Fin: 2026-07-14

Líder del proyecto

LEIBNIZINSTITUT FUER PHOTONISCHE TECHNOLOGIEN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 190K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The ExoDiagAI project is at the forefront of addressing a critical challenge in modern healthcare—early diagnosis and effective management of breast cancer, particularly the aggressive and elusive triple-negative breast cancer (TNBC) subtype. TNBC lacks well-defined molecular targets, hindering treatment options. Exosomes, a subset of extracellular vesicles with unique functions, hold great promise as diagnostic and prognostic markers for various diseases, including cancer. These tiny vesicles are abundant in biological fluids but have been underutilized due to the absence of a cost-effective isolation protocol. Our primary goal is to develop a microfluidic device, integrating nano-lateral displacement arrays with a Raman biochip, to identify exosome biomarkers specific to TNBC and translate this knowledge into clinical practice. This project's main objectives encompass creating the microfluidic device, assessing its surface-enhanced Raman spectroscopy (SERS) capabilities, conducting Raman fingerprinting of exosomes from in vitro cell cultures and patient samples, and employing chemometric analysis to discriminate biomarkers. The distinctive Raman fingerprinting associated with exosomes serves as a promising prognostic and diagnostic marker. By introducing 3D printing SERS technology, we aim to enable real-time monitoring, shedding light on exosome structural integrity. This interdisciplinary project combines organic, inorganic, nano, computational, spectroscopic, and molecular biology techniques, culminating in innovative device fabrication. Ultimately, the ExoDiagAI project holds the potential to revolutionize early breast cancer diagnosis through exosomal biomarkers, aligning with the EU's sustainable development strategy for advanced diagnostic platforms and fostering the career of a promising researcher. This endeavor marks a pivotal step towards enhancing the detection and management of TNBC, addressing a pressing healthcare need.

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