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NIR-emitting Ag-DNAs

Financiado

Elucidating the Structural Origin of NIR-Emission from Ag-DNA

The interest in atomically precise metal cluster systems has grown over the last decades due to the physicochemical properties that emerge at the nanoscale compared to the bulk regime. Despite promising features, stability often h... ver más

30/09/2026

UCPH

215K€

Presupuesto del proyecto: 215K€

Líder del proyecto

KOBENHAVNS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-03-21

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023 ExpectedOutcome:Project results are expected to contribute to the following outcomes:

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Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UCPH

214.93K€ | Lider

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Duración del proyecto: 30 meses Fecha Inicio: 2024-03-21
Fecha Fin: 2026-09-30

Líder del proyecto

KOBENHAVNS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 215K€

Descripción del proyecto The interest in atomically precise metal cluster systems has grown over the last decades due to the physicochemical properties that emerge at the nanoscale compared to the bulk regime. Despite promising features, stability often hinders their use in real-life applications. Since stabilization is critical, DNA has been proven to be a functional and versatile scaffold for luminescent silver clusters. DNA oligomers are intrinsically biocompatible and are able to tune the emission color and promote high photoluminescence efficiencies. Near-infrared emitting DNA-stabilized silver nanoclusters (NIR-emitting Ag-DNAs) are promising candidates for several potential applications, such as bioimaging and sensing, due to improved cell and tissue penetration of NIR light. The development of NIR emissive Ag-DNAs currently needs to be improved by three main challenges: extremely limited structural information (only one is available), absence of a rationale for designing NIR-emitting Ag-DNAs with high luminescence yield, and poor understanding of This project aims to address these gaps by first synthesizing and screening a wealth of NIR-emitting Ag-DNAs and then employing state-of-the-art techniques, such as pair distribution function analysis and X-ray absorption spectroscopy, to characterize the best-performing candidates structurally. Establishing a structure-luminescence rationale for NIR-emitting Ag-DNAs will be the ultimate goal of the project. Such findings are paramount to performing electronic structure calculations, and it is the needed input for machine learning algorithms to predict NIR-emitting Ag-DNAs with tailored optical properties. The results of this proposal will thus pave the way for a myriad of different applications.

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