Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

ORBIT

Financiado

Elucidating the nano-biointeractions on DNA origami

The forces governing the nano-biointeractions are essential to understand the biological behaviour and pharmacokinetics of the nanostructures. So far, these understandings have been limited to nanoparticles. However, it should be... ver más

14/09/2025

USC

181K€

Presupuesto del proyecto: 181K€

Líder del proyecto

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 236

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-05-15

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 ExpectedOutcome:

I+D

Cerrada hace 2 años

0% 100%

1 Participantes

USC

181.15K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

CTQ2014-57515-C2-2-R RECONOCIMIENTO MOLECULAR EN MATRICES NANOESTRUCTURADAS PARA... 67K€ Cerrado

DNANOMETAL Design of metal-stabilized DNA and RNA nanoconstructs potent... 215K€ Cerrado

CTQ2014-57515-C2-1-R INTERFASES NANOESTRUCTURADAS DE DERIVADOS DEL ADN PARA RECON... 67K€ Cerrado

MAT2013-46101-R SINTESIS Y ENSAMBLAJE REPRODUCIBLES DE NANOESTRUCTURAS PLASM... 258K€ Cerrado

CodeSphere CodeSphere Discovering Therapeutic Nanoparticles by Molecu... 150K€ Cerrado

PID2021-128417OB-I00 NANOBOTS BIOCOMPATIBLES COMO NANOVEHICULOS EFICIENTES PARA A... 284K€ Cerrado

Duración del proyecto: 27 meses Fecha Inicio: 2023-05-15
Fecha Fin: 2025-09-14

Líder del proyecto

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA No se ha especificado una descripción o un objeto social para esta compañía.

Total investigadores 236

Presupuesto del proyecto 181K€

Descripción del proyecto The forces governing the nano-biointeractions are essential to understand the biological behaviour and pharmacokinetics of the nanostructures. So far, these understandings have been limited to nanoparticles. However, it should be noted that the NPs´ chemical synthetic methods render non-homogeneous dispersions, even when low polydispersity is reached. In addition, the modification of NPs with a specific number of ligands is still challenging and there is no agreement about the most effective configuration or number of ligands to achieve efficient targeting in vivo. The programmability of the DNA-nanostructures (origamis) allows the synthesis of predictable and controllable sizes and shapes with almost atomic precision. In addition, the origamis can also be designed to include additional molecules, with high accuracy on the valency and the orientation. Thus, this technology offers a powerful tool to study and understand the biological behaviour of objects at the nanoscale since precise control over the size, shape and attachment of molecules can be achieved when other methods are unable to. Based on the structural organization and spatial distribution of natural and specific bionanoparticles, such as viruses, this project will exploit the atomic programmability of origamis to design a library of DNA nanostructures inspired on viral particles. The biomolecular corona will be studied to understand its impact on origamis´ biodistribution, a topic still not studied yet. Finally, the cell response will be evaluated in terms of targeting and immune response. These results will help to a better understanding of the mechanism between nano-structures and living systems and to formulate guidelines to synthesize more efficient nanomedicines. Overall, this project will allow me to carry out a 2-year project independently, growing towards a mature, professional and independent researcher in the DNA nanotechnology field, reinforcing my expertise on the nanomedicine field.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores