Elucidating the causes and consequences of the global pattern of epigenetic vari...
Elucidating the causes and consequences of the global pattern of epigenetic variation in Arabidopsis thaliana
Epigenetics continues to fascinate, especially the notion that it blurs the line between nature and nurture and could make Lamarckian adaptation via the inheritance of acquired characteristics possible. That this is in principle p...
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Información proyecto EPICLINES
Duración del proyecto: 72 meses
Fecha Inicio: 2018-05-15
Fecha Fin: 2024-05-31
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
Epigenetics continues to fascinate, especially the notion that it blurs the line between nature and nurture and could make Lamarckian adaptation via the inheritance of acquired characteristics possible. That this is in principle possible is clear: in the model plant Arabidopsis thaliana (Thale cress), experimentally induced DNA methylation variation can be inherited and affect important traits. The question is whether this is important in nature. Recent studies of A. thaliana have revealed a pattern of correlation between levels of methylation and climate variables that strongly suggests that methylation is important in adaptation. However, somewhat paradoxically, the experiments also showed that much of the variation for this epigenetic trait appears to have a genetic rather than an epigenetic basis. This suggest that epigenetics may indeed be important for adaptation, but as part of a genetic mechanism that is currently not understood. The goal of this project is to determine whether the global pattern of methylation has a genetic or an epigenetic basis, and to use this information to elucidate the ultimate basis for the global pattern of variation: natural selection.