Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

TOPOGRAPHYSENSING

Financiado

Cerrado

Effects of 3D topographies on mechanosensing in intestine epithelial architectur...

Effects of 3D topographies on mechanosensing in intestine epithelial architecture and dynamics Intestine epithelium consists of spatially segregated cells that organize into groups of various functions at different locations of the 3D curved epithelial monolayer. How geometric cues contribute to the maintenance of the sophi... ver más

31/08/2021

CNRS

197K€

Presupuesto del proyecto: 197K€

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-08-31

MSCA-IF-2018: Individual Fellowships

I+D

Cerrada hace 6 años

0% 68% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

CNRS

134.60K€ | Lider

Proyectos interesantes

MolCellTissMech

Medical Technol...

Applied Physics

2M€ Cerrado

TensionControl

Medical Technol...

Applied Physics

2M€ Cerrado

BFU2016-79916-P

Medical Technol...

Applied Physics

327K€ Cerrado

BIOMECAMORPH

Medical Technol...

Applied Physics

2M€ Cerrado

PushingCell

Medical Technol...

Applied Physics

10M€ Cerrado

JDC2023-051559-I

Medical Technol...

Applied Physics

72K€ Cerrado

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 28 meses Fecha Inicio: 2019-04-10
Fecha Fin: 2021-08-31

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 197K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Intestine epithelium consists of spatially segregated cells that organize into groups of various functions at different locations of the 3D curved epithelial monolayer. How geometric cues contribute to the maintenance of the sophisticated epithelial architecture and dynamics in 3D remains unknown until now. Recently, the Ladoux's laboratory has found that EpCAM-modulated cell contractility associated with the epithelial monolayer polarity, cytoskeletal arrangement, and cell-cell adhesion in 3D context. In contrast to 2D context, the EpCAM-defective tissue shows a loss of collective cellular spatial organization and forms a disordered multi-layered epithelium when exposed to substrates of 3D topographies. In addition, Ankyrin-G and α/β-spectrin network which participates in cortical tension modulation was identified as the main interacting partner with EpCAM in epithelial cells. These observations lead us to hypothesize that EpCAM allows the tissue to sense and conform to complex 3D topographies in an orderly manner. However, the molecular mechanisms and other related functions of EpCAM-mediated mechanotransduction remain unknown. As large scale mechanosensing has been shown to occur primarily through the actin cytoskeleton which permeates the tissue to form a network, we aim to understand the interactions between the EpCAM-mediated pathway and actin modulation and/or E-cadherin adhesion sites that may allow 3D topographical sensing. Our working hypothesis is that EpCAM forms an integral part of the cellular responses to topographic cues that has a more general role in controlling epithelial architecture and dynamics through the regulation of actomyosin networks, or vice versa. Here, we propose to scrutinize EpCAM-mediated mechanotransduction by generating a platform with precise control of geometric factors and microenvironmental cues using a range of multidisciplinary approaches including microfabrication, biophysics, and advanced molecular biology techniques.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores