Innovating Works

RosaLind

Financiado
Ecogenomics of Mosquito Microbe Symbiosis for Novel Control Strategies of Infect...
Ecogenomics of Mosquito Microbe Symbiosis for Novel Control Strategies of Infectious Diseases The burden of mosquito-transmitted diseases such as Plasmodium, Dengue, West Nile, Zika, Usutu, or yellow fever continue to increase globally, representing one of the most significant public health threats. In the context of insec... The burden of mosquito-transmitted diseases such as Plasmodium, Dengue, West Nile, Zika, Usutu, or yellow fever continue to increase globally, representing one of the most significant public health threats. In the context of insecticide resistance concomitant to the absence of an efficient vaccine, new strategies that focus on mosquito’s microbiota are being developed. In particular the widespread intracellular bacterium Wolbachia, which can limit pathogen transmission and hijack host reproduction, represents one of the most promising tools to control the transmission of disease. Nevertheless, the genomic variability of Wolbachia and its mobilome, together with its influence on pathogen blocking, in interaction with other symbiotic Life in naturally infected vectors, remains largely unknown. In this project, I plan to dissect the mechanisms of interaction between Wolbachia, commensal (healthy) bacterial communities and pathogens, using cutting-edge ‘omics’ and molecular approaches. 1.Wolbachia variants: I will use shotgun metagenomes to reconstruct Wolbachia and other symbiotic genomes and investigate the links between Wolbachia genetic variability, density and protection in naturally infected individuals at the organ level. I will explore the extent and potential role of Wolbachia phages in mutualistic traits such as defense through differential expression analyses in native conditions and controlled infection within Culex spp. 2.Midgut microbiota: I will explore the diversity, variability, role, and interaction of midgut symbionts with arboviruses through 16S amplicon sequencing and expression analyses in experimental infections conditions in Culex spp. 3.pWCP: I will investigate the transformation and expression capacity of the first and newly discovered Wolbachia plasmid element. If successful, a Wolbachia transformation technology would represent a new tool for vector control strategies and potentially have a great impact for public health worldwide. ver más
31/08/2026
INRAE
1M€
Duración del proyecto: 69 meses Fecha Inicio: 2020-11-03
Fecha Fin: 2026-08-31

Línea de financiación: concedida

El organismo H2020 notifico la concesión del proyecto el día 2020-11-03
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
ERC-2020-STG: ERC STARTING GRANTS
Cerrada hace 5 años
Presupuesto El presupuesto total del proyecto asciende a 1M€
Líder del proyecto
INSTITUT NATIONAL DE RECHERCHE POUR LAGRICULT... No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5