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Early Detection of cancer onset based on sensing field cancerization at the orga...

Early Detection of cancer onset based on sensing field cancerization at the organ level Cancer is a major cause of death worldwide. Gastrointestinal (GI) tract tumors are among the most common and deadliest ones. Despite progress in imaging and treatment, the social impact of these diseases is enormous. All parties i... ver más

31/10/2022

BIOMEDICAL RESEARC...

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHI... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2022-10-31

FETOPEN-01-2016-2017: FET-Open research and innovation ac...

I+D

Cerrada hace 8 años

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7 Participantes

BIOMEDICAL RESEARCH FOUNDATI...

541.81K€ | Lider

UC3M

362.19K€ | Participante

EXELIXIS RESEARCH MANAGEMENT...

134.63K€ | Participante

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Duración del proyecto: 53 meses Fecha Inicio: 2018-05-03
Fecha Fin: 2022-10-31

Líder del proyecto

IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHI... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Cancer is a major cause of death worldwide. Gastrointestinal (GI) tract tumors are among the most common and deadliest ones. Despite progress in imaging and treatment, the social impact of these diseases is enormous. All parties in the health sector agree that prevention and/or early diagnosis is the most effective means to deal with cancer. Currently, cancer is identified most often when symptomatic or large enough to be visualized in body scans or when histological alterations are already present. What is lacking is an imaging method that could detect tissue changes that facilitate or predict tumor development at an early stage. These alterations, collectively referred to as field cancerization is an exciting field of study in cancer biology with profound ramifications in clinical practice. Molecular mechanisms underlying field cancerization are being studied and the advances in molecular biology facilitate these studies. Never in the past however, have these changes been sensed/measured by an imaging modality at the organ level. We thus propose the development of a multimodal microscopy platform that will allow sensing of Raman and scattering properties at the organ level, in order to identify molecular and structural fingerprints of early stage disease in the GI tract. Successful implementation will allow the development of an endoscope especially designed for this purpose that will be used to detect early stage cancer in humans.

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