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ELIMINATE-CKD

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Cerrado

Early detection, molecular mechanisms and therapeutic interventions in chronic k...

Early detection, molecular mechanisms and therapeutic interventions in chronic kidney disease The objective of ELIMINATE-CKD is to demonstrate that combining measures of kidney structure and function will strongly enhance detection of chronic kidney disease (CKD). To reach this objective, I will develop a new method to qua... ver más

31/08/2029

UNIVERSITAIR MEDIS...

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

ACADEMISCH ZIEKENHUIS GRONINGEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-09-01

ERC-2023-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

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UNIVERSITAIR MEDISCH CENTRUM...

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Duración del proyecto: 59 meses Fecha Inicio: 2024-09-01
Fecha Fin: 2029-08-31

Líder del proyecto

ACADEMISCH ZIEKENHUIS GRONINGEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The objective of ELIMINATE-CKD is to demonstrate that combining measures of kidney structure and function will strongly enhance detection of chronic kidney disease (CKD). To reach this objective, I will develop a new method to quantify the number of nephrons, the smallest functional units in the kidney.Rationale:- CKD affects ~10% of the global population and causes 2.6 million deaths/year. CKD-associated costs (140 billion euros/year in Europe) exceed diabetes and cancer. Limitations in CKD detection impede the success of emerging therapies.- Current CKD definition is based on creatinine-based estimated glomerular filtration rate, which is often inaccurate due to interindividual differences in body composition and compensation for early kidney damage as remaining nephrons increase their function.- Using a unique combination of multi-omics and machine learning approaches in human cohorts and innovative animal models, I will dissect pathways that drive nephron number and enable its quantification.Concrete objectives are to:1) Develop a high-throughput method to quantify nephron number in large human cohorts and a novel rat model of gradual nephron reduction2) Construct and validate unbiased and hypothesis-driven nephron number algorithms based on kidney-derived proteins, lipids and metabolites in blood and urine3) Demonstrate that nephron number algorithms enable earlier and more accurate CKD detection4) Provide proof of principle that nephron number-triggered therapy prevents or halts CKDImpact:This project will lead to a new CKD classification, based on both structure and function. Identification of mechanisms driving nephron number will boost drug development and regenerative medicine towards nephron-preserving therapies. Finally, the concept of structure-function relationship is relevant in many other organs (brain, heart). My passion to beat kidney disease by innovative diagnostics drives me towards my ultimate goal: to eliminate CKD.

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