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D-PhosMate

Financiado

Dynamic Peptide-Phosphate-based Hydrogels for Modelling Diseases and Therapeutic...

Dynamic Peptide-Phosphate-based Hydrogels for Modelling Diseases and Therapeutic Interventions Supramolecular biomaterials represent a promising solution to address complex challenges in advanced therapies and disease modelling platforms. D-PhosMate’s overarching aim is to explore different formulation strategies and molecu... ver más

31/05/2026

I3S INSTITUTO DE...

157K€

Presupuesto del proyecto: 157K€

Líder del proyecto

I3S INSTITUTO DE INVESTIGACAO E INOVACAO EM... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-03-01

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023

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Cerrada hace 1 año

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1 Participantes

I3S INSTITUTO DE INVESTIGAC...

156.78K€ | Lider

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Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 26 meses Fecha Inicio: 2024-03-01
Fecha Fin: 2026-05-31

Presupuesto del proyecto 157K€

Descripción del proyecto Supramolecular biomaterials represent a promising solution to address complex challenges in advanced therapies and disease modelling platforms. D-PhosMate’s overarching aim is to explore different formulation strategies and molecular designs based on enzymes, natural phosphate-containing units, and peptide amphiphile building blocks, to generate self-assembling hydrogels with time-dependent mechanical and degradation properties as vehicles for the delivery of living therapeutics (generated in situ) and in vitro extracellular matrix models along disease progression. These biocompatible hydrogels will exhibit enzyme-instructed biomechanical and chemical tuneability, which represent versatile platforms that will be leveraged for two applications. First, for the post-operative treatment of glioblastoma multiforme (the most aggressive malignant brain tumour), and second, for understating the molecular mechanisms responsible for ectopic calcifications (the mineralisation of the extracellular matrix of soft tissues like kidneys, joints, heart valves, and arteries, among others). Outcomes from the project will benefit several communities, including peptide and supramolecular chemistry, biomaterials science, bioengineering, cancer, and cardiovascular medicine, among others. All of this, while providing advanced training and career development opportunities for a young researcher at the intersection of advanced biomaterials design, peptide nanotechnology, and precision medicine. Molecular tools provided by D-PhosMate will increase available cancer therapeutic choices and will contribute to improving the translation of preclinical research, enhancing success rates of clinical trials (with a consequent multibillion-dollar impact) and the life quality improvement of patients in need of innovative therapies.

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