DAHAD
Financiado
Dual Antibacterial Hydrogel ADhesives
Nowadays, available surgical skin closure techniques still remain painful and are prone to infections. To assess these challenges, DAHAD aims to develop new hydrogels with a dual action: biological tissues adhesion and antibacteri...
Nowadays, available surgical skin closure techniques still remain painful and are prone to infections. To assess these challenges, DAHAD aims to develop new hydrogels with a dual action: biological tissues adhesion and antibacterial activity. The hydrogels will be prepared by the gelation of biomimetic dendrimer-polymer hybrids in aqueous solutions. These hybrids will be composed of a central linear polymer, namely Pluronic® F-127, decorated at its extremities with multiple biomimetic catechol moieties to confer biological adhesive properties to the gels. The hydrogels will be loaded with diverse hydrophilic and lipophilic antibiotics to locally deliver them into the surgical site and prevent infections. DAHAD contemplates (i) the organic synthesis of the dendrimer-polymer hybrids, (ii) the hydrogels preparation and the study of their adhesiveness, physicochemical characterization and thermo-responsiveness (iii) the drug delivery of hydrophilic and lipophilic antibiotics throughout the hydrogels by direct diffusion or assisted by micellar nanoparticles and their skin biocompatibility (iv) and the back loop enhancement of the gelation abilities, adhesion and drug delivery results using hydrogen bonding (H-bonding) supramolecular chemistry.
DAHAD is built as a multidisciplinary and international project along which the Purdue University (USA), the Universidad de Zaragoza (Spain) and the Instituto de Nanociencia y Materiales de Aragón (Spain) will combine their efforts and expertise to pursue the planned R&I objectives, as well as the dissemination of the results to scientific, industrial and public audiences. It aims to boost the applicant’s career, to complement the expertise of INMA in biomaterials for medical applications and be the kick-starter of a solid, international and successful collaborative network.
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Duración del proyecto: 36 meses
Fecha Inicio: 2022-05-30
Fecha Fin: 2025-05-31
Fecha Fin: 2025-05-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-05-30
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2021-PF-01-01:
MSCA Postdoctoral Fellowships 2021
Cerrada
hace 3 años
Presupuesto
El presupuesto total del proyecto asciende a
187K€
Líder del proyecto
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA...
Investigaciones agrarias
Perfil tecnológico
TRL
2-3
716M
Perfil tecnológico
TRL
2-3
716M
N.D. |
Participante