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The G-Q-reat ESKAPE

Financiado

Druggability of G-quadruplexes, promising modulators for antimicrobial resistanc...

Druggability of G-quadruplexes, promising modulators for antimicrobial resistance The antimicrobial resistance (AMR) is an underrated problem promoted by widespread misuse and massive use of antibiotics. Thus, the health systems are facing enormous costs to treat nosocomial infections due to AMR bacteria. In pa... ver más

31/08/2025

UNISI

173K€

Presupuesto del proyecto: 173K€

Líder del proyecto

UNIVERSITA DEGLI STUDI DI SIENA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-07-07

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 ExpectedOutcome:

I+D

Cerrada hace 2 años

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1 Participantes

UNISI

172.75K€ | Lider

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Duración del proyecto: 25 meses Fecha Inicio: 2023-07-07
Fecha Fin: 2025-08-31

Líder del proyecto

UNIVERSITA DEGLI STUDI DI SIENA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 173K€

Descripción del proyecto The antimicrobial resistance (AMR) is an underrated problem promoted by widespread misuse and massive use of antibiotics. Thus, the health systems are facing enormous costs to treat nosocomial infections due to AMR bacteria. In particular, six highly virulent bacteria (E.S.K.A.P.E.) are the main responsible for worldwide nosocomial infections. In the last years, our research strategies to discover and develop new clinically relevant antibiotics lacked effectiveness. As a result, we are unable to efficiently treat AMR infections and are unprepared to face an AMR bacteria outbreak. One possible strategy is to target bacteria G-quadruplexes (bGQs) which are highly conserved DNA/RNA secondary structures pivotal for bacteria duplication, transcription and translation. This strategy is particular effective because, when a new pathogen emerges, its DNA/RNA genome is first disclosed through sequencing, hence the ability of quickly designing new drug candidates based only on this information will be a powerful tool to face a new epidemic/pandemic. Furthermore, the human GQs (hGQs) were largely investigated as possible target for anticancer treatment thus the interest in bGQs raised later and with less intensity than hGQs. In addition, most GQs modulators bind G-quartets top by π-stacking interactions and the druggability of GQs loops/grooves was still not addressed. In this context, the multidisciplinary of G-Q-reat ESKAPE project aims to provide a novel and effective strategy to contrast AMR by targeting bGQs and to expand the knowledge on bGQs.

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