Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

DropMicS

Financiado

Droplet printable microfluidic arrays for high-throughput screening of 3D cell c...

Droplet printable microfluidic arrays for high-throughput screening of 3D cell culture This project will develop high-throughput 3D cell culture devices with perfusion by interfacing microfluidics and droplet printing technologies and subsequently applying them to model neuro-development disorders. For decades, 2D c... ver más

31/05/2026

ESPCI Paris

196K€

Presupuesto del proyecto: 196K€

Líder del proyecto

ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDU... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 3 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-03-20

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023 ExpectedOutcome:Project results are expected to contribute to the following outcomes:

I+D

Cerrada hace 1 año

0% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

ESPCI Paris

195.91K€ | Lider

INSERM

N.D. | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

uBeat Mimic human complexity in a Beat to revolutionize the drug d... 75K€ Cerrado

GALILEO The first wide range flow sensor to unlock microfluidic cell... 2M€ Cerrado

PID2021-122409OB-C22 ANALISIS CUANTITATIVO DE ORGANOIDES DERIVADOS DE PACIENTES D... 145K€ Cerrado

SYNEBIO High-throughput combinatory drugs testing on in vitro 3D cel... 150K€ Cerrado

PTQ-16-08396 Bone-on-Chip Analysis Platform for In vitro Drug Performance... 84K€ Cerrado

CPP2021-008396 SISTEMA MICROFLUIDICO PARA APLICACIONES EN TEJIDO EN UN CHIP 378K€ Cerrado

Duración del proyecto: 26 meses Fecha Inicio: 2024-03-20
Fecha Fin: 2026-05-31

Líder del proyecto

ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDU... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 196K€

Descripción del proyecto This project will develop high-throughput 3D cell culture devices with perfusion by interfacing microfluidics and droplet printing technologies and subsequently applying them to model neuro-development disorders. For decades, 2D cell culture followed by animal testing has been the standard for therapeutic drug discovery. 3D systems have the potential to recreate more faithful physiological conditions (cell interactions, gradients, perfusion, flow). Thus, they are expected to be more predictive for efficacy and toxicity than 2D systems and minimize the use of animals. However, there is currently no 3D model which enables high-throughput (HT) and perfusion at once: spheroids and organoids in plates can be HT but without perfusion, pressure-driven microfluidics has perfusion but is not HT, droplet microfluidics is HT but cannot handle large drug libraries and has no perfusion. Here, we will leverage the physics of wetting and capillarity to design chamber arrays with liquid-trapping geometries, which can be entirely operated by external droplet injection. We will set up designs and protocols for the embedding of cells in 3D hydrogel matrices and submit them to perfusion of medium and drug, including uniform or gradient conditions in each chamber. We will demonstrate the HT interfacing with droplet printers. Finally, we will apply the device to screen compounds and monitor the modulation of microglia (the immune cell of the brain) inflammation that affects the lives of >2 million preterm babies every year.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores