Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MONOCHROME

Financiado

Cerrado

Disentangling metaphase chromosome organisation one chromosome at a time

Chromosomes assume their most compact state during metaphase just before they are separated. In this process of cell division the chromosomes experience high forces and genomic defects can occur then. Many techniques have built co... ver más

31/12/2025

STICHTING VU

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

STICHTING VU No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-05-13

ERC-2019-ADG: ERC Advanced Grant

I+D

Cerrada hace 5 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

STICHTING VU

2.00M€ | Lider

SOWRE CONSULTING ESPAÑA SL E...

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

CHROMAVISION Super resolution visualisation and manipulation of metaphase... 4M€ Cerrado

IJCI-2017-31831 Decoding the structure of chromatin and DNA by super-resolut... 64K€ Cerrado

ChromaSTORM Visualising how proteins fold DNA into topologically associa... 175K€ Cerrado

Chromosome periphery Assembly and function of the chromosome periphery during mit... 179K€ Cerrado

MITOFOLD Revealing the structure and mechanism of mitotic chromosome... 3M€ Cerrado

CCC Chromosome Condensation and Cohesion 100K€ Cerrado

Duración del proyecto: 67 meses Fecha Inicio: 2020-05-13
Fecha Fin: 2025-12-31

Líder del proyecto

STICHTING VU No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Chromosomes assume their most compact state during metaphase just before they are separated. In this process of cell division the chromosomes experience high forces and genomic defects can occur then. Many techniques have built considerable understanding of metaphase chromosome structure and a multitude of models have been put forward how cells organize their chromosomes during metaphase. Yet, given the complexity of the process and limitations of the methods to study them, it is far from being fully understood. The breakthrough opportunity in this regard is the development of tools that allow real-time, 3D, super-resolution imaging and manipulation of entire non-fixed metaphase chromosomes under nearphysiological conditions. Here I propose to quantitatively image the proteins that establish the architecture of metaphase chromosomes and disentangle the connection between its architecture, internal protein dynamics and mechanics at the multi-protein as well as the single-molecule level. For this project I plan to expand the combination of optical manipulation and fluorescent microscopy by introducing force-induced expansion microscopy together with advanced labeling and imaging techniques that ultimately will permit real-time, 3D, super-resolution quantitative analysis of complex (protein) structures within native non-fixed metaphase chromosomes. With this kind of instrument it becomes possible to validate and/or challenge the current models of metaphase organization as well as explore the physical properties of chromosomes but also study chromosome separation dynamics. My extensive experience handling biological systems and pushing instrumental boundaries gives me an excellent starting point to address key research questions with regards to metaphase chromosomes. In doing so I can improve our understanding of chromosome organization which is important because chromosome defects can have devastating consequences leading to for example cancer or fragile X syndrome.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores