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AUTISMS-3D

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Disability versus Difference over Development in the Autisms

Autism is an early developing condition diagnosed on the basis of difficulties in the domains of social-communication and restricted repetitive behaviors. However, the single label of ‘autism’ masks a large degree of heterogeneity... see more

31/12/2028

IIT

2M€

Project Budget: 2M€

Project leader

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

PARTICIPATION DEPralty Sin fecha límite de participación.

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Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2023-06-02

ERC-2022-COG: ERC CONSOLIDATOR GRANTS Scope:Objectives

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characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

IIT

1.22M€ | Leader

THE REGENTS OF THE UNIVERSIT...

LOS ANGELES UCLA SANTA BARBA...

778.88K€ | participant

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Project duration: 66 months Date Start: 2023-06-02
End date: 2028-12-31

Project leader

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Project Budget 2M€

participation deadline Sin fecha límite de participación.

Project description Autism is an early developing condition diagnosed on the basis of difficulties in the domains of social-communication and restricted repetitive behaviors. However, the single label of ‘autism’ masks a large degree of heterogeneity at multiple scales, from genome to phenome, and may not signal differential needs and services required for some types of profoundly affected individuals. In order to better understand autism and develop more impactful ways to facilitate positive outcomes at an individualized-level, we need better models that help to explain how autism may be differentiated in meaningful ways that help explain variability in developmental paths, responses to treatment, and differential underlying neurobiological mechanisms. This research program develops and tests the AUTISMS-3D model – disability versus difference over development - as a first-level major distinction for explaining heterogeneity within the autism population. AUTISMS-3D postulates that the major first-level split within the autism population is between subtypes described by profound disability versus difference in developmental outcomes. Stratification models using standardized clinical measures of intellectual functioning, language, and adaptive behavior will be used to predict ‘disability’ versus ‘difference’ subtypes. These stratification models are based on highly reproducible data-driven clustering analyses from very large phenotypic datasets. We will then test how the subtypes may develop differently with analyses of big clinical longitudinal datasets and also within the context of early intervention. Finally, we will test the subtypes for neurobiological differences via neuroimaging (MRI, fMRI, DTI) and electrophysiological (EEG) and gaze phenotypes (e.g., eye tracking) under static and naturalistic viewing conditions. The research will help refine our understanding and concepts of autism and will be an important next step on the path to precision medicine for the autisms.

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