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Directed Evolution of Photoredox Powered Artificial Metalloenzymes for Stereodiv...

Directed Evolution of Photoredox Powered Artificial Metalloenzymes for Stereodivergent Catalysis Artificial metalloenzymes have recently emerged as powerful tools to address the ever-growing requirements of chemistry to become more efficient and sustainable. This methodology involves anchoring a reactive transition metal cata... ver más

31/03/2021

UNIVERSITAT BASEL

191K€

Presupuesto del proyecto: 191K€

Líder del proyecto

UNIVERSITAT BASEL No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-03-31

MSCA-IF-2018: Individual Fellowships

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Cerrada hace 6 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

UNIVERSITAT BASEL

191.15K€ | Lider

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Duración del proyecto: 24 meses Fecha Inicio: 2019-03-21
Fecha Fin: 2021-03-31

Líder del proyecto

UNIVERSITAT BASEL No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 191K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Artificial metalloenzymes have recently emerged as powerful tools to address the ever-growing requirements of chemistry to become more efficient and sustainable. This methodology involves anchoring a reactive transition metal catalyst within a protein to exploit the secondary coordination sphere created around the new active site, which can induce selectivity in reactions and improve turnover numbers. Concomitantly, photoredox and metallophotoredox catalysis, where a small quantity of a light sensitive compound allows non-traditional reactivity though open shell reactive intermediates, has also developed dramatically in recent years. The impressive reaction repertoire is especially synthetically attractive due to the mild conditions required and the ability to activate abundant and generally more inert functional groups. However, the current drawback to this methodology is the high levels of control needed to give the reactions their full synthetic potential. This is where the two fields display complementarity with an unexplored interface: Photoredox Artificial Metalloenzymes. By anchoring a nickel catalyst inside an enzyme pocket with a nearby photocatalyst, it should be possible to control catalytic reactivity by mutagenesis of residues in the secondary coordination sphere. In the proposed case of an sp3-sp3 cross-coupling reaction between a racemic amino acid derivative and bromoalkane, this could potentially allow control over both new stereocentres independently to achieve stereodivergent catalysis. It is subsequently proposed that this methodology could be adapted to include intramolecular cross-coupling reactions, which would beneficially allow access to the valuable monocyclic β-lactam scaffold from suitably functionalised linear substrates. If possible, this may allow efficient access to diastereoisomers potentially difficult to access by other means, which may hold unexplored pharmaceutical potential.

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