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Neurotwin

Financiado

Cerrado

Digital twins for model driven non invasive electrical brain stimulation

Neuropsychiatric disorders are a leading cause of global disability-adjusted life years, and solutions are lacking. Can digital twins be useful? At least in some cases, we hold they will be central to progress. Recent findings su... ver más

30/06/2025

NEUROELECTRICS BAR...

4M€

Presupuesto del proyecto: 4M€

Líder del proyecto

NEUROELECTRICS BARCELONA SLU El desarrollo y comercializacion de productos y servicios en el area de la neurociencia

TRL 4-5 | 3M€

Fecha límite participación Sin fecha límite de participación.

Ver 8 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-12-02

FETPROACT-EIC-07-2020: FET Proactive: emerging paradigms a...

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8 Participantes

NEUROELECTRICS BARCELONA SLU

844.75K€ | Lider

BETH ISRAEL DEACONESS MEDICA...

313.52K€ | Participante

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Duración del proyecto: 54 meses Fecha Inicio: 2020-12-02
Fecha Fin: 2025-06-30

Líder del proyecto

NEUROELECTRICS BARCELONA SLU El desarrollo y comercializacion de productos y servicios en el area de la neurociencia

TRL 4-5 | 3M€

Presupuesto del proyecto 4M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Neuropsychiatric disorders are a leading cause of global disability-adjusted life years, and solutions are lacking. Can digital twins be useful? At least in some cases, we hold they will be central to progress. Recent findings suggest that non-invasive brain stimulation may be a valuable option in conditions such as epilepsy or Alzheimer's (AD). Still, a better understanding of mechanisms and patient-specific factors is needed. Personalized hybrid brain models uniting the physics of electromagnetism with physiology – neurotwins or NeTs – are poised to play a fundamental role in understanding and optimizing the effects of stimulation at the individual level. We ambition to deliver disruptive solutions through model-driven, individualized therapy. We will build a computational framework – weaved and validated across scales and levels of detail– to represent the mechanisms of interaction of electric fields with brain networks and assimilate neuroimaging data. This will allow us to characterize the dynamical landscape of the individual brain and define strategies to restore healthy dynamics. Benefitting from existing databases of healthy and AD individuals, we will deliver the first human and rodent NeTs predicting the effects of stimulation on dynamics. We will then collect detailed multimodal measurements in mice and humans to improve the predictive power of local and whole-brain models under the effects of electrical stimulation, and translate these findings into a technology pipeline for the design of new personalized neuromodulation protocols which we will test in a cohort of AD patients and healthy controls in randomized double-blinded studies. With research at the intersecting frontier of nonlinear dynamics, network theory, biophysics, engineering, neuroscience, clinical research, and ethics, Neurotwin will deliver model-driven breakthroughs in basic and clinical neuroscience, with patients ultimately benefiting from safe, individualized therapy solutions.

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