Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

DEFEND

Financiado

Dietary shaping of the early life metabolome and its role in healthy lung and br...

Dietary shaping of the early life metabolome and its role in healthy lung and brain development Asthma and behavioral problems related to neurodevelopmental delay such as ADHD and autism are common childhood disorder with lack of insight in disease mechanisms and no preventive measures, which is an unmet medical and societal... ver más

31/01/2026

REGIONH

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

REGION HOVEDSTADEN No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 3 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2021-01-29

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2020-STG: ERC STARTING GRANTS

I+D

Cerrada hace 5 años

0% 100%

3 Participantes

REGIONH

1.45M€ | Lider

JUAN ROMANI ESTEVE

683.92K€ | Participante

GRL

45.17K€ | Participante

Proyectos interesantes

AGL2011-24014 ESTUDIO MULTIDISCIPLINAR DE LA SUPLEMENTACION MATERNA DURANT... 103K€ Cerrado

SAF2015-69265-C2-1-R BUSQUEDA DE MARCADORES PRECOCES DEL NEURODESARROLLO EN HIJOS... 121K€ Cerrado

FEM2015-63631-R EFECTOS DE LA SUPLEMENTACION PERINATAL CON DHA SOBRE EL ESTR... 97K€ Cerrado

AGL2009-12374-C03-03 MECANISMO DE ACCION DE LOS ACIDOS GRASOS POLIINSATURADOS DE... 218K€ Cerrado

CNS2023-143985 Psicología 200K€ Cerrado

BFU2012-40254-C03-02 PAPEL DE LOS ACIDOS GRASOS DURANTE LA PRIMERA ETAPA DE LA VI... 82K€ Cerrado

Últimas noticias

25-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 52 concesiones

25-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 1 concesiones

25-11-2024: FUNDACION-EOI En las últimas 48 horas el Organismo FUNDACION EOI ha otorgado 6 concesiones

Duración del proyecto: 60 meses Fecha Inicio: 2021-01-29
Fecha Fin: 2026-01-31

Líder del proyecto

REGION HOVEDSTADEN

TRL 4-5

Presupuesto del proyecto 1M€

Descripción del proyecto Asthma and behavioral problems related to neurodevelopmental delay such as ADHD and autism are common childhood disorder with lack of insight in disease mechanisms and no preventive measures, which is an unmet medical and societal need. In the Danish COPSAC mother-child cohort, I showed in two randomized trials that pregnancy supplements with n-3 long-chained polyunsaturated fatty acids (n-3 LCPUFA) and high-dose vitamin D reduced offspring asthma risk, improved cognitive scores and accelerated language and milestone achievement, which was replicated in the American VDAART vitamin D trial. This holds the promise for primary prevention but establishing underlying biochemical mechanisms and effect modification by maternal and early life diet and host genetics remains to achieve a personalized preventive strategy targeting supplements only to those women, whose offspring will benefit from it. This research project aims to understand how dietary supplements and diet in pregnancy and early life shapes the child’s metabolism and how this is linked to asthma and neurodevelopment, using longitudinal untargeted and targeted metabolomics profiles from more than 1,500 mother-child pairs in COPSAC and VDAART, detailed data on maternal and infant diet, the early life exposome, and genetics and genomics data. The objective is to identify metabolites and biochemical pathways of importance for asthma and neurodevelopment, focusing on n-3/n-6 LCPUFAs, sphingolipids and tryptophan, with the ultimate goal to achieve healthy lung and brain development through personalized diet interventions during pregnancy. The transdisciplinary study group lead by the applicant consisting of MDs with pediatric, respiratory and psychiatric expertise, wet and dry lab metabolomics experts and bioinformaticians will bridge basic and clinical sciences in an international collaboration between COPSAC, Denmark, and VDAART at Harvard Medical School, US.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores