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PLEC2021-007968

Financiado

Development of New Technologies to Track Emerging Infectious Threats in Wildlife...

Development of New Technologies to Track Emerging Infectious Threats in Wildlife and the Environment (NEXTHREAT) Emerging infectious diseases (EIDs) are one of the most important threats for the livestock industry with a serious socio-economic impact worldwide. Global changes linked to human activity, including climatic changes, deeply affec... ver más

01/01/2021

CSIC

550K€

Presupuesto del proyecto: 550K€

Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Financiación concedida El organismo AGENCIA ESTATAL DE INVESTIGACIÓN notifico la concesión del proyecto el día 2021-01-01

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29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

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Líder del proyecto

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA...

TRL 2-3 | 552M€

Presupuesto del proyecto 550K€

Descripción del proyecto Emerging infectious diseases (EIDs) are one of the most important threats for the livestock industry with a serious socio-economic impact worldwide. Global changes linked to human activity, including climatic changes, deeply affect the rise and distribution of these diseases, creating new opportunities for them to thrive in unexpected hosts, new ecological niches or wider geographical areas. As a result, outbreaks of emerging diseases are more frequent, posing an important threat both to livestock production and public health, as many EIDs are zoonotic. Most EIDs are caused by viruses. Hence, by tracking the animal and environmental virus pool it is possible to detect viruses that may cause the next emerging diseases affecting livestock and humans. The here described NEXTHREAT proposal consists of a One Health approach to explore already available technologies for tracking the environmental & wildlife virus pool in order to implement effective strategies for the detection of emerging viruses, potentially harmful for livestock and human health, and thus enable their prevention and control. NEXTHREAT counts with an interdisciplinary consortium involving long-experienced collaborating groups representing the three One Health sectors, coordinated by the Emerging and Transboundary Diseases Group at the Animal Health Research Center (CISA, INIA:CSIC), partnered with the National Reference Laboratories for Public Health at ISCIII and the Doñana Biological Station (EBD-CSIC) as well as two international industrial partners: Roche Diagnostics Spain and INGENASA, leaders in the animal and public health diagnostic sector. Our proposal follows an interdisciplinary strategy gathering experts from all the relevant scientific areas to tackle this challenge, from virology to molecular biology, biotechnology, bioinformatics, veterinary diagnostics, ecology, epidemiology and entomology.NEXTHREAT will take benefit of existing molecular technologies available at the consortium, from metagenomic approaches for unbiased detection of virus genomes to multiplex antigen arrays for detection of antibodies to a range of important emerging pathogens in livestock. NEXTHREAT aims at implementing these powerful assays at field-scale in order to assess their suitability in emerging virus surveillance. The proposal can be considered as a proof-of-concept study focusing on specific geographic areas in Spain with known potential for releasing newly emerging viruses (hot spots), which will be screened for viruses at the environmental-livestock interface. For economy of resources, the approach is based on a selection of elements or matrices known to have a key role as reservoirs of emerging viruses from which spillover to livestock, and eventually to humans, usually takes place. These matrices belong to three categories: animal (vertebrate) samples, arthropod (vector) samples and environmental (water) samples. These samples will be surveyed using the above-mentioned technologies. As a prominent expected result of this strategy, an exhaustive molecular characterization of viruses circulating in the wildlife/environmental-livestock interface will be achieved, together with data of livestock exposure to most relevant viruses, acquired by multiplex antibody assays. Analysis of spillover risks associated with these viruses will hopefully result in a priority list of risk viruses against which we will target our efforts for developing virus-specific diagnostic tests and predictive maps of high-risk areas for virus emergence, aimed at enabling a better prevention and control of emerging diseases. The results of this proof-of-concept will potentially guide further studies beyond the here explored geographic and ecological limits: If successful, this approach may become a chief strategy for the animal and public authorities in each country to reinforce capacity to prevent the impact of the next EIDs on animal and human health, and reduce their spread risk.

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