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IVBM-4PAP

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Cerrado

Development of an In-Vivo Brillouin Microscope (with application to Protein Aggr...

Development of an In-Vivo Brillouin Microscope (with application to Protein Aggregation-based Pathologies) The role and importance of mechanical properties of cells and tissues in cellular function, development and disease has widely beenacknowledged, however standard techniques currently used to assess them exhibit intrinsic limitatio... ver más

31/08/2026

IIT

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-01

HORIZON-EIC-2022-PATHFINDEROPEN-01-01: EIC Pathfinder Open 2022 Scope:You should apply to this call if you are looking for support from EIC Pathfinder Open to reali...

I+D

Cerrada hace 2 años

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IIT

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Duración del proyecto: 41 meses Fecha Inicio: 2023-03-01
Fecha Fin: 2026-08-31

Líder del proyecto

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto The role and importance of mechanical properties of cells and tissues in cellular function, development and disease has widely beenacknowledged, however standard techniques currently used to assess them exhibit intrinsic limitations (invasive, lack of 3D capabilityand of sub-cellular resolution). Recently, Brillouin Microscopy (BM), a type of optical elastography, has emerged as a non-destructive,label- and contact-free method that can probe the viscoelastic properties of biological samples with diffraction-limited resolution in3D. This led to increased attention amongst the biological and medical research communities. However, due to the long acquisitiontime (hours), this novel technique has been applied only to fixed samples. One important open challenge is to use this approach tofollow the mechano-biological processes in living cells and in real time. Aim of our project is overcome the spectral-imagingacquisacknowledged, however standard techniques currently used to assess them exhibit intrinsic limitations (invasive, lack of 3D capability and of sub-cellular resolution). Recently, Brillouin Microscopy (BM), a type of optical elastography, has emerged as a non-destructive, label- and contact-free method that can probe the viscoelastic properties of biological samples with diffraction-limited resolution in 3D. This led to increased attention amongst the biological and medical research communities. However, due to the long acquisition time (hours), this novel technique has been applied only to fixed samples. One important open challenge is to use this approach to follow the mechano-biological processes in living cells and in real time. Aim of our project is overcome the spectral-imaging acquisition time limitation by applying the heterodyne detection scheme, allowing the collection of viscoelastic properties in living sample at a sub-second timescale. We will attempt solving specific physio-pathological open problems in biomedicine for the first time.

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