IVBM-4PAP
Financiado
Development of an In-Vivo Brillouin Microscope (with application to Protein Aggr...
Development of an In-Vivo Brillouin Microscope (with application to Protein Aggregation-based Pathologies)
The role and importance of mechanical properties of cells and tissues in cellular function, development and disease has widely beenacknowledged, however standard techniques currently used to assess them exhibit intrinsic limitatio...
The role and importance of mechanical properties of cells and tissues in cellular function, development and disease has widely beenacknowledged, however standard techniques currently used to assess them exhibit intrinsic limitations (invasive, lack of 3D capabilityand of sub-cellular resolution). Recently, Brillouin Microscopy (BM), a type of optical elastography, has emerged as a non-destructive,label- and contact-free method that can probe the viscoelastic properties of biological samples with diffraction-limited resolution in3D. This led to increased attention amongst the biological and medical research communities. However, due to the long acquisitiontime (hours), this novel technique has been applied only to fixed samples. One important open challenge is to use this approach tofollow the mechano-biological processes in living cells and in real time. Aim of our project is overcome the spectral-imagingacquisacknowledged, however standard techniques currently used to assess them exhibit intrinsic limitations (invasive, lack of 3D capability and of sub-cellular resolution). Recently, Brillouin Microscopy (BM), a type of optical elastography, has emerged as a non-destructive, label- and contact-free method that can probe the viscoelastic properties of biological samples with diffraction-limited resolution in 3D. This led to increased attention amongst the biological and medical research communities. However, due to the long acquisition time (hours), this novel technique has been applied only to fixed samples. One important open challenge is to use this approach to follow the mechano-biological processes in living cells and in real time. Aim of our project is overcome the spectral-imaging acquisition time limitation by applying the heterodyne detection scheme, allowing the collection of viscoelastic properties in living sample at a sub-second timescale. We will attempt solving specific physio-pathological open problems in biomedicine for the first time.
ver más
Duración del proyecto: 41 meses
Fecha Inicio: 2023-03-01
Fecha Fin: 2026-08-31
Fecha Fin: 2026-08-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-01
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-EIC-2022-PATHFINDEROPEN-01-01:
EIC Pathfinder Open 2022
Cerrada
hace 2 años
Presupuesto
El presupuesto total del proyecto asciende a
3M€
Líder del proyecto
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5