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MAIT-TraDe

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Development and trafficking of type 1 and type 17 mucosal-associated invariant T...

Development and trafficking of type 1 and type 17 mucosal-associated invariant T cells Mucosal-associated invariant T (MAIT) cells colonize mucosal tissues where they become tissue-resident and have important protective and homeostatic functions. MAIT cells are selected in the thymus by microbial metabolites present... ver más

31/08/2026

INSTITUT CURIE FON...

196K€

Presupuesto del proyecto: 196K€

Líder del proyecto

INSTITUT CURIE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-08-10

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 ExpectedOutcome:

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Cerrada hace 2 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

INSTITUT CURIE FONDATION

195.91K€ | Lider

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Duración del proyecto: 36 meses Fecha Inicio: 2023-08-10
Fecha Fin: 2026-08-31

Líder del proyecto

INSTITUT CURIE No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 196K€

Descripción del proyecto Mucosal-associated invariant T (MAIT) cells colonize mucosal tissues where they become tissue-resident and have important protective and homeostatic functions. MAIT cells are selected in the thymus by microbial metabolites presented by MHC-related protein 1 (MR1) on thymocytes thereby acquiring an effector phenotype (type 1 or 17). This project aims at elucidating mechanisms that regulate the last stages of thymic MAIT cell development, including their egress, and identify cues necessary for tissue colonization. Specifically, we will couple transcriptomics and thymus transplantation models to analyze canonical thymic MAIT cell development, thereby identifying new regulators of the MAIT1/17 fates, as well as to identify MAIT cells that recently exited the thymus and seeded mucosal organs, thereby identifying new regulators of tissue adaptation. These targets will be functionally tested in models combining CRISPR/Cas9 encoded by lentivirus with bone-marrow chimeras or adoptive transfers. Additionally, we will determine the identity and dynamics of MAIT cells exiting the thymus to colonize tissues by combining different experimental approaches including in vivo EdU/biotin labeling, thymectomy and blockage of thymus egress. Lastly, we will address whether MR1–microbial metabolites are required for the maintenance of MAIT cells in tissues at steady-state using mono-colonization/decolonization of germ-free mice and by conditionally ablating Mr1. Overall, this work will uncover fundamental mechanisms underlying MAIT cell development and tissue colonization. Albeit outside the scope of this work, it is possible that the mechanisms uncovered here may have implications in other innate-like T cells or for the establishment of mainstream tissue-resident T cells.

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