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OMEGA

Financiado

Developing technologies to engineer plant genomes at the megabase scale

Genomics research combined with revolutionary genome editing tools has created new opportunities to explore fundamental aspects of biology and develop novel (bio)technologies for medicine, agriculture, and industry. The OMEGA proj... ver más

30/06/2027

VLAAMS INSTITUUT...

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

VIB VZW No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-05-19

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2021-STG: ERC STARTING GRANTS

I+D

Cerrada hace 3 años

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1 Participantes

VLAAMS INSTITUUT BIOTECHNOL...

1.50M€ | Lider

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Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 61 meses Fecha Inicio: 2022-05-19
Fecha Fin: 2027-06-30

Líder del proyecto

VIB VZW

TRL 4-5

Presupuesto del proyecto 1M€

Descripción del proyecto Genomics research combined with revolutionary genome editing tools has created new opportunities to explore fundamental aspects of biology and develop novel (bio)technologies for medicine, agriculture, and industry. The OMEGA project is designed to build on these developments by enabling Megabase-scale engineering of plant genomes. Experimentally-determined lists of essential genes have been crucial for such large-scale projects in other species but are currently unavailable in plants. Therefore, the OMEGA project needs to determine which plant genes are essential for growth and development. However, the standard technologies used to identify essential genes are limited by genetic interactions (e.g. redundancy, synthetic lethality). My group is developing multiplex CRISPR screens in plants to specifically overcome these limitations. The OMEGA project will use this capability to identify genome-wide essential genes and genetic interactions in Physcomitrium patens. This will be the first systematic genetic interaction screen in plants and will likely identify interactions conserved across the green lineage. The OMEGA project will also develop technologies to move, edit, and delete DNA at the Megabase scale. As proof-of-concept, I aim to reduce ~10% of the P. patens genome and remove all non-essential DNA from one chromosome. The SCRaMbLE system will be adapted for P. patens and used as an alternative approach to minimize chromosomes and also perform in planta directed evolution. Lastly, we will use a DNA assembly method developed in my lab to build biosynthetic pathways in vivo using modular DNA assembly methods. These tools will create opportunities to explore fundamental aspects of genomics, chromosomal biology and synthetic biology. The objectives of project OMEGA are necessarily ambitious as these technologies will allow us to perform controlled, Megabase-scale engineering projects in plant genomes not possible with the current generation of genome editing tools.

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