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VICT3R

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Developing and implementing VIrtual Control groups To reducE animal use in toxic...

Developing and implementing VIrtual Control groups To reducE animal use in toxicology Research VICT3R, a public-private partnership running under the European Innovative Health Initiative, aims to significantly reduce the number of animals used in experimental studies performed during the nonclinical drug and chemical safet... ver más

29/02/2028

Líder desconocido

26M€

Presupuesto del proyecto: 26M€

Líder del proyecto Líder desconocido

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-07-26

HORIZON-JU-IHI-2023-05-03: Improved prediction, detection, and... Expected Impact:Patients will be offered accelerated access to the healthcare system through improve...

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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37 Participantes

INCYTE BIOSCIENCES DISTRIBUT...

MERCK HEALTHCARE KGAA

BARCELONA SUPERCOMPUTING CEN...

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Duración del proyecto: 43 meses Fecha Inicio: 2024-07-26
Fecha Fin: 2028-02-29

Líder del proyecto Líder desconocido

Presupuesto del proyecto 26M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto VICT3R, a public-private partnership running under the European Innovative Health Initiative, aims to significantly reduce the number of animals used in experimental studies performed during the nonclinical drug and chemical safety evaluation by replacing the animals of the concurrent controls groups (CCGs) with Virtual Control Groups (VCGs). These VCGs will be generated by means of state-of-the-art statistical or artificial intelligence (AI) approaches that optimally exploit the wealth of historical data from control animals accumulated over decades by pharmaceutical companies and other relevant industrial and academic sectors. The VCG concept was conceived and prototyped during the recently finished eTRANSAFE IMI2 project for its application in the nonclinical safety assessment of the pharmaceutical industry. A preliminary evaluation of the VCG concept carried out in the eTRANSAFE project demonstrated that it is generally feasible, yet scientifically and operationally challenging and must therefore be refined before its adoption for regulatory hazard and risk assessment. The main challenges consist of adequate data collection and curation, identification of key variables to achieve optimal matching between VCGs and CCGs, and validation of procedures including compliance with Good Laboratory Practice (GLP). These challenges will be systematically tackled in VICT3R for achieving the full development and regulatory acceptance of the VCG concept. VICT3R will collect, curate and analyse large data sets of control animals from different species to produce a large high-quality database. The database will be made available to VICT3R partners, regulators, and policy makers with the purpose to allow maturation of the VCG concept and to prove its validity, reproducibility and robustness. While VICT3R will be primarily focused on repeated dose toxicity studies, the extension of the VCG concept to other types of studies involving animals will also be tackled. VICT3R will promote that its database and software platform is maintained and expanded long term.

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