Developing an Adverse Outcome Pathway for metabolic Nuclear Receptor binding co...
Developing an Adverse Outcome Pathway for metabolic Nuclear Receptor binding compounds in Atlantic cod
Environmental contaminants are accumulating in oceans and marine food webs and thereby pose a risk for both ecosystem and human health. In my MSCA-project, I aspire to bring the field of environmental toxicology to the next level...
ver más
¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video
Proyectos interesantes
INTERNAL EXPOSURE
Internal exposure in tissue equilibrium sampling to bridge...
177K€
Cerrado
CGL2008-01898
HERRAMIENTAS TOXICOGENOMICAS PARA LA EVALUACION DE RIESGO AM...
228K€
Cerrado
CTM2017-90890-REDT
RED CIENTIFICA DE ANALISIS DE RIESGO Y EXPOSICION A CONTAMIN...
17K€
Cerrado
BES-2010-041179
EVALUACION DE LOS RIESGOS DE SALUD PUBLICA DEBIDOS A TOXINAS...
43K€
Cerrado
CGL2008-01888
RECEPTORES RXR/PPAR: NUEVAS HERRAMIENTAS PARA LA DETECCION D...
149K€
Cerrado
PCI2021-121933
PRESENCE,BEHAVIOR AND RISK ASSESSMENT OF PHARMACEUTICALS IN...
75K€
Cerrado
Información proyecto NRgCod
Duración del proyecto: 41 meses
Fecha Inicio: 2021-03-15
Fecha Fin: 2024-09-07
Líder del proyecto
HOGSKULEN PA VESTLANDET
No se ha especificado una descripción o un objeto social para esta compañía.
Presupuesto del proyecto
202K€
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
Environmental contaminants are accumulating in oceans and marine food webs and thereby pose a risk for both ecosystem and human health. In my MSCA-project, I aspire to bring the field of environmental toxicology to the next level by applying my track-record in developing Adverse Outcome Pathways (AOPs) in the model organism zebrafish to the sentinel species Atlantic cod. The renowned Environmental Toxicology laboratory of Prof. Anders Goksøyr at the University of Bergen (UiB), is specialised in interactions of human-made chemicals with nuclear receptors (NRs) in Atlantic cod. Contaminant activated NRs can be the initiating molecular event leading to a cascade of responses, disrupting energy metabolism and culminating in an adverse outcome at behavioural level. At UiB, I will be trained in applying the precision-cut liver slicing technique and in developing in vitro luciferase reporter assays to identify NR activity after exposure to major legacy and emerging contaminants. I will then translate my knowledge on mechanisms leading to behavioural effects in zebrafish larvae, to the Atlantic cod. I will be supported by the Environmental Chemistry Group at the Institute of Marine Research (secondment) providing expertise on larval Atlantic cod toxicology and lipid chemistry. Developing AOPs in an ecologically relevant species is a young field of research but of high relevance to defining the ecological consequences of contaminant exposures. This project will innovatively expedite the Environmental Toxicology research and underline my ambitions to become an independent academic group leader. I will further sharpen my academic profile by profiting from UiB’s unique Centre of Excellence in Biology Education (bioCEED) which will enhance my skills in modern supervising and teaching techniques. The proposal addresses pressing scientific questions by integrating the expertise and network of both the host and me while shaping my profile on the way to become a leading scholar.