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Peptide Osteogel

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Cerrado

Determining novel peptide sequence and matrix mechanical properties to increase...

Determining novel peptide sequence and matrix mechanical properties to increase osteogenesis in embryonic stem cells using designer alginate hydrogels for bone regeneration Regenerating large bone defects is a great challenge in regenerative medicine. Embryonic stem cell (ESC) therapies are an attractive option due to their unlimited proliferation and ability to produce the cell types needed for bon... ver más

28/02/2013

IMPERIAL COLLEGE O...

201K€

Presupuesto del proyecto: 201K€

Líder del proyecto

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo FP7 notifico la concesión del proyecto el día 2013-02-28 No tenemos la información de la convocatoria

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

IMPERIAL COLLEGE OF SCIENCE...

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Líder del proyecto

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND ME... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 201K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Regenerating large bone defects is a great challenge in regenerative medicine. Embryonic stem cell (ESC) therapies are an attractive option due to their unlimited proliferation and ability to produce the cell types needed for bone repair. Here, we propose creating a three-dimensional alginate hydrogel that displays bioactive epitopes and has mechanical properties that induce osteogenic differentiation of ESCs and increase bone formation in vitro. We will do this by building upon previous research in the group of Prof Molly Stevens, which found that ESCs cultured on the extracellular matrix of bone forming osteoblasts increased both differentiation into osteogenic cells and bone formation. We propose using a proteomic approach to identify the proteins that are responsible for this effect. Once the proteins are known, they will be cut into short overlapping peptides that will be synthesized and attached to a cell culture surface. ESCs will then be grown on them to determine the sequences that induce osteogenesis. Using two-dimensional hydrogels of different stiffness that are coated with the osteogenic peptide, the mechanical properties that maximize osteogenesis will be determined. This peptide will then be coupled to alginate to form a hydrogel whose mechanical properties will be tailored to maximize bone formation. Novel sequences which induce osteogenesis are important to stem cell biology and an artificial matrix that differentiates ESCs into osteoblasts using both displayed ligands and stiffness would be important to regenerative medicine. The project Peptide Osteogel will be beneficial to Europe by bringing a scientist with a unique skill set into a top biomaterials lab to work on a multidisciplinary project that will increase the quality and status of science in the European Union. This fellowship will enable greater collaboration and transfer of knowledge across Europe, increasing the mobility and human potential of scientists across the continent.

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