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DNANOMETAL

Financiado

Design of metal-stabilized DNA and RNA nanoconstructs potentially applicable in...

DNA nanotechnology can provide breakthroughs in various fields such as catalysis, nanofabrication, computation, bioimaging, drug delivery or cancer treatment. This approach is based on the idea that if single-stranded DNA sequence... ver más

31/08/2026

UCPH

215K€

Presupuesto del proyecto: 215K€

Líder del proyecto

KOBENHAVNS UNIVERSITET No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-05-07

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023

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1 Participantes

UCPH

214.93K€ | Lider

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Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 27 meses Fecha Inicio: 2024-05-07
Fecha Fin: 2026-08-31

Líder del proyecto

KOBENHAVNS UNIVERSITET

TRL 4-5

Presupuesto del proyecto 215K€

Descripción del proyecto DNA nanotechnology can provide breakthroughs in various fields such as catalysis, nanofabrication, computation, bioimaging, drug delivery or cancer treatment. This approach is based on the idea that if single-stranded DNA sequences are not perfectly complementary, branched-stranded DNAs can be formed, from which complex 2D or 3D structures can be constructed with near-atomic precision by proper sequence design. Although DNA nanomaterials seem to be promising, the biomedical application is significantly challenged by the fact that current DNA - and especially RNA - nanostructures are unstable under physiological conditions, sensitive towards nucleases and oxidative damage as well. Therefore my main goal is to develop more stable DNA nanostructures that can later be used to stabilize vaccines or drug carriers. For this purpose I will use metal-mediated base pairing in addition to the classical Watson-Crick hydrogen base pairing. During the project I will design, purify and analyse oligonucleotides that stabilize silver nanoclusters (AgNCs) in the small size regime with mixed Ag0/AgI composition in order to achieve AgNC-oligonucleotide systems (nanoconstructs), that can remain stable even in the conditions of the human plasma, thus can be used later as vaccines or drug carriers. This approach is beyond state of the art since it was not even mentioned as a possible application of metal-incorporated DNA nanoconstructs in the most recent reviews of the field, although already existing data combined suggests, it could eliminate many of the issues of previous concepts. I will use modern separation, spectroscopy and structure quantification methods, as well as cellular studies, to design and characterise the system that best meets the criteria.

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