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DREAMS

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Describing the Role of the Epstein-Barr virus And S1PR inhibition in the pathoge...

Describing the Role of the Epstein-Barr virus And S1PR inhibition in the pathogenesis of Multiple Sclerosis Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). One million people in Europe have MS, experiencing a significantly reduced quality of life and dying 7-14 years younger than average. The annu... ver más

31/08/2027

UNIVERSITY OF LIME...

311K€

Presupuesto del proyecto: 311K€

Líder del proyecto

UNIVERSITY OF LIMERICK No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-05-16

HORIZON-MSCA-2022-PF-01-01: MSCA Postdoctoral Fellowships 2022 ExpectedOutcome:

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2 Participantes

UNIVERSITY OF LIMERICK

310.64K€ | Lider

UZH

N.D. | Participante

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Duración del proyecto: 51 meses Fecha Inicio: 2023-05-16
Fecha Fin: 2027-08-31

Líder del proyecto

UNIVERSITY OF LIMERICK No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 311K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). One million people in Europe have MS, experiencing a significantly reduced quality of life and dying 7-14 years younger than average. The annual burden on European economies is ~€35B. Epstein-Barr virus (EBV) infects almost all Europeans and is aetiologically linked to MS with infection increasing disease risk 32-fold. Despite the huge personal, societal and economic impacts of MS, the underlying role of EBV in its development remains poorly understood. DREAMS will explore how EBV contributes to MS development. To do this, the Postdoctoral Fellow (PF) will utilise a novel humanised mouse model which harbours the major genetic risk factor for MS and is permissive for EBV infection. This model displays characteristics common with human MS, including CNS immune cell infiltration. Applying multiplex immunofluorescence, the PF will explore the nature of this immune infiltrate and how it is influenced by drugs used to treat MS, focussing on inhibitors of S1PR signalling. Combined with mechanistic in vitro studies to determine how these drugs interact with EBV-infected B-cells and EBV-specific T-cells, this work will allow new insights into how S1PR modulation affects MS immunopathology. As such, this research aligns with the Horizon Europe Health cluster and several UN sustainable goals, and meets Open Science, Gender Equality, Supervision and Green Charter guidelines. The PF will receive training in humanised mouse models, in vivo imaging and flow cytometry during an outgoing 24-month phase at the University of Zurich (Switzerland). This will be followed by a 12-month return phase at the University of Limerick (Ireland), learning in vitro T-cell assays. The PF will leverage the interdisciplinary supervisory team to meet the research & training objectives outlined, in preparation for an independent research career in the field of virus-associated diseases.

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