Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

PANDEMIC

Financiado

Defusing mini-chromosomes—the Achilles’ heel of the wheat blast pandemic

PANDEMIC is an ambitious high-risk/high-gain program to deliver an innovative pathogen-guided strategy for crop disease resistance. The wheat blast pandemic is a clear and present danger to global food security. It is caused by th... ver más

30/09/2028

MPG

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

MAXPLANCKGESELLSCHAFT ZUR FORDERUNG DER WISSE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-05-26

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

ERC-2022-STG: ERC STARTING GRANTS

I+D

Cerrada hace 2 años

0% 100%

1 Participantes

MPG

1.50M€ | Lider

Proyectos interesantes

PowR Powdery Mildew Resistance 215K€ Cerrado

PID2020-120188RJ-I00 BASES MOLECULARES DE REGULACION DEL CICLO CELULAR EN LA ENFE... 182K€ Cerrado

PID2020-113153RB-I00 DESCIFRANDO EL DIALOGO MOLECULAR Y LOS MECANISMOS DE RESISTE... 150K€ Cerrado

AGL2008-05687-C02-02 BASES GENETICAS Y MOLECULARES LIGADAS A LA RESISTENCIA A PLA... 85K€ Cerrado

PCIN-2013-064 GENES Y MUTANTES IMPLICADOS EN LA INFECCION POR VIRUS EN CAN... 100K€ Cerrado

PCIN-2013-056 COMBINACION DE BIOLOGIA DE SISTEMAS Y ABORDAJES EXPERIMENTAL... 100K€ Cerrado

Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 64 meses Fecha Inicio: 2023-05-26
Fecha Fin: 2028-09-30

Presupuesto del proyecto 1M€

Descripción del proyecto PANDEMIC is an ambitious high-risk/high-gain program to deliver an innovative pathogen-guided strategy for crop disease resistance. The wheat blast pandemic is a clear and present danger to global food security. It is caused by the blast fungus, Magnaporthe oryzae, which, after emerging in Brazil only ~35 years ago, has spread over the last 5 years to Southeast Asia and Africa. We discovered that all isolates of the pandemic wheat blast fungus belong to a single, asexual clonal lineage. These pandemic isolates carry a supernumerary mini-chromosome (mChr) of ~2 Mb, which encodes 19 secreted effector (virulence) proteins and renders the pandemic lineage highly virulent. We propose that this mChr is the Achilles’ heel of the pandemic fungus. In PANDEMIC, my team and I will target the mChr virulence properties by gene editing and engineering of disease resistance genes that target mChr-encoded effectors. The central hypothesis of this project is, that detailed knowledge about the biophysical properties of pathogen effector-host target interactions can guide bioengineering of non-transgenic disease resistance in wheat. To achieve our goal, we will employ a multi-disciplinary approach combining genetics, structural biology, and gene editing. Specifically, we will pursue the following objectives: 1. GENETICS. Determine the mChr-encoded effectors conferring high virulence on the pandemic wheat blast fungus. 2. BIOPHYSICS. Define the biophysical properties of effector-host target interactions. 3. IMMUNITY. Apply CRISPR/Cas gene editing to deliver innovative, non-transgenic solutions for blast disease management. At the completion of this project, my team and I will generate a detailed understanding of the biophysical properties of mChr-encoded effector-target protein complexes and deliver novel traits and non-transgenic solutions for developing resistance against the pandemic wheat blast fungus.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores