T2Lead
Financiado
Define a lead candidate for clinical development of a novel T cell therapy
Acute myeloid leukemia (AML) is a disease with a poor prognosis, especially for such patients either failing initial treatment or relapsing thereafter. In AML, specific immune cells such as T cells have been proven to bear curativ...
Acute myeloid leukemia (AML) is a disease with a poor prognosis, especially for such patients either failing initial treatment or relapsing thereafter. In AML, specific immune cells such as T cells have been proven to bear curative potential in the context of stem cell transplantation but toxicity and therapy failure are frequent. The use of T cells modified for specificity with chimeric antigen receptors (CAR) has changed the landscape of several blood-borne cancer of the B cell lineage. In AML, however, ongoing development of CAR T cells is associated with severe toxicities, limiting dosing and efficacy because of poor specificity of used targets for AML blasts. In my ERC funded research, I have identified unique AML targets which are not shared with healthy hematopoesis or other relevant healthy organs. Developing CAR against these, I could demonstrate the potential of my strategy. To enable clinical development and exploitation, T2LEAD will identify and develop lead CAR candidates for further translation. T2LEAD will explore the medical and commercial potential of lead CAR and route exploitation towards licensing or spin out or both. T2LEAD will be supported by a strong network of advisors from academia, industry and regulation frame work. Ultimately T2LEAD will help advancing the treatment landscape in AML to the benefit of AML patients.
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Duración del proyecto: 23 meses
Fecha Inicio: 2023-03-13
Fecha Fin: 2025-02-28
Fecha Fin: 2025-02-28
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-03-13
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
ERC-2022-POC2:
ERC PROOF OF CONCEPT GRANTS2
Cerrada
hace 2 años
Presupuesto
El presupuesto total del proyecto asciende a
150K€
Líder del proyecto
LUDWIGMAXIMILIANSUNIVERSITAET MUENCHEN
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5