ViROSCa
Financiado
Deciphering the roles of reactive oxygen species and calcium during viral infect...
Deciphering the roles of reactive oxygen species and calcium during viral infection in Arabidopsis
As sessile organisms, plants always have to deal with different environmental stimuli. The generation of reactive oxygen species (ROS) and calcium flux as second messengers are one of the common strategies to respond to such stimu...
As sessile organisms, plants always have to deal with different environmental stimuli. The generation of reactive oxygen species (ROS) and calcium flux as second messengers are one of the common strategies to respond to such stimuli. Upon perception of pathogens, molecular warning signals (ROS and calcium) propagate cell-to-cell to trigger defence mechanisms. However, the precise roles of ROS and calcium during viral infection process and the associated signalling mechanism remain largely unknown. Viruses are obligate intracellular pathogens that hijack host machineries to facilitate their replication and propagation across the plant through plasmodesmata, communication channels bridging the plant cells. The ViROSCa project’s goal is to explore the mutual role of generated ROS and calcium signals and to study the crosstalk between the two signals during viral infection and later identify the virus element(s) that specifically induce(s) such signals. I will integrate Arabidopsis genetics, biosensors, genome editing technology (CRISPR/Cas9) and advanced microscopy techniques to decipher the roles of plasma membrane (PM)-located ROS- and calcium related candidate proteins and PM organisation (nanodomains) during the plant virus infection process. The novelty of the project is the use of a powerful pathosystem and biosensors to study the crosstalk between ROS and calcium signalling.
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Duración del proyecto: 23 meses
Fecha Inicio: 2023-10-01
Fecha Fin: 2025-09-30
Fecha Fin: 2025-09-30
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-10-01
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2022-PF-01-01:
MSCA Postdoctoral Fellowships 2022
Cerrada
hace 2 años
Líder del proyecto
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE...
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5