Hola,
¿eres nuevo aquí?

Registrate y conecta tu empresa con financiación pública, partners y proyectos.

MIMETIC

Financiado

Deciphering the role of the Mycobacterium tuberculosis exometabolome in mycobact...

Deciphering the role of the Mycobacterium tuberculosis exometabolome in mycobacterial virulence Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), exhibits an intracellular lifestyle, thriving within host macrophages. This remarkable ability to evade macrophage-mediated killing and withstand the chal... ver más

31/05/2026

CNRS

196K€

Presupuesto del proyecto: 196K€

Líder del proyecto

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-03-18

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023

I+D

Cerrada hace 1 año

0% 100%

1 Participantes

CNRS

195.91K€ | Lider

Proyectos interesantes

PID2019-110240RB-I00 MECANISMOS DE VESICULACION EN MICOBACTERIAS Y SU CONEXION CO... 182K€ Cerrado

PID2021-123443OB-I00 MECANISMOS MOLECULARES IMPLICADOS EN LAS DIFERENCIAS DE PATO... 194K€ Cerrado

SAF2016-77433-R VESICULAS EXTRACELULARES MICOBACTERIANAS: BIOGENESIS Y APLIC... Cerrado

PID2019-104690RB-I00 DESARROLLO DE TERAPIAS ANTI-VIRULENCIA Y ESTUDIO DE LA ADAPT... 139K€ Cerrado

PCIN-2013-041 UNA APROXIMACION OMICA AL DIAGNOSTICO DE LA TUBERCULOSIS Cerrado

PRE2020-096507 DESARROLLO DE TERAPIAS ANTI-VIRULENCIA Y ESTUDIO DE LA ADAPT... 99K€ Cerrado

Últimas noticias

29-11-2024: IDAE En las últimas 48 horas el Organismo IDAE ha otorgado 4 concesiones

29-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 2 concesiones

29-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 37 concesiones

Duración del proyecto: 26 meses Fecha Inicio: 2024-03-18
Fecha Fin: 2026-05-31

Presupuesto del proyecto 196K€

Descripción del proyecto Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), exhibits an intracellular lifestyle, thriving within host macrophages. This remarkable ability to evade macrophage-mediated killing and withstand the challenges posed by the host environment hinges largely on its exceptional capacity to adapt its metabolism in response to the diverse conditions encountered during infection. Despite progress, our comprehension of Mtb metabolic adjustments in these circumstances remains limited. Preliminary investigations conducted within the host laboratory have unveiled that Mtb releases a multitude of small, soluble molecules into its extracellular milieu when cultured in vitro. These metabolites potentially exert a substantial influence at the host-pathogen interface, subsequently shaping the delicate equilibrium established between the bacterium and its host throughout the course of infection. This proposal is centered on elucidating the role of Mtb exometabolome at host-pathogen interface, with the overarching objectives of (i) advancing our insight into Mtb metabolism and (ii) pinpointing potential novel virulence determinants that might be secreted by the microorganism. The primary phase involves the comprehensive identification and quantification of metabolites present in the bacterial culture medium. This will be achieved through untargeted metabolomics methodologies, primarily utilizing NMR and mass spectrometry. Subsequently, the metabolic pathways governing the biosynthesis and secretion of these metabolites will be characterized. This investigation seeks to unravel the underlying metabolic drivers facilitating the release of these compounds. The culmination of this project involves exploring the impact of a subset of significant metabolites on the physiology of infected macrophages, as well as their role in modulating the immune response. These assessments will encompass a spectrum of in vitro and in vivo strategies.

Conecta tu I+D

Entra hoy

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores