Hola,
Are you new here?

RBNAGE

financed

Deciphering the role of RNA biological noise in aging using long-reads transcrip...

Deciphering the role of RNA biological noise in aging using long-reads transcriptomics. The ultimate goal of this proposal is to decipher the role of the RNA biological noise (RBN) in the ageing brain. RBN represents a rare but real pool of RNA molecules generated as a result of transcriptional instability. However,... see more

31/08/2026

CSIC

165K€

Project Budget: 165K€

Project leader

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

PARTICIPATION DEPralty Sin fecha límite de participación.

Ver 3 Participantes

Financing granted El organismo HORIZON EUROPE notifico la concesión del proyecto The day 2024-05-12

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023 Expected Outcome:Project results are expected to contribute to the following outcomes:

I+D

Cerrada does 1 year

0% 100%

characteristics of the participant

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Private Information

No hay información privada compartida para este proyecto. Habla con el coordinador.

3 Participantes

CSIC

165.31K€ | Leader

CORNELL UNIVERSITY

N.D. | participant

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Project duration: 27 months Date Start: 2024-05-12
End date: 2026-08-31

Project leader

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 2-3 | 552M€

Project Budget 165K€

participation deadline Sin fecha límite de participación.

Project description The ultimate goal of this proposal is to decipher the role of the RNA biological noise (RBN) in the ageing brain. RBN represents a rare but real pool of RNA molecules generated as a result of transcriptional instability. However, as the RBN can only be extracted by full-length single-molecule transcript sequencing, whether RBN is associated with decline processes such as aging and neurodegeneration, remains to be elucidated. To evaluate this association, I will use readily-available data, including long-reads, single cell and spatial transcriptomics of aging mice brains. First, I will develop a methodology to distinguish technical noise from RBN in long-reads transcriptomics. Second, I will characterize the RBN to decipher its contribution to aging. Third, I will study the cell-type-specific and brain-region-specific RBN. To carry out this project, I will work with Dr. Conesa, expert in long-reads transcriptomics, method development and multi-omics. This timely work will benefit from collaboration with world leaders in single-molecule technologies participating in MSCA-DN 2021 LongTREC to study transcriptome biology under the coordination of Dr. Conesa. Successful completion of this project will contribute insights and software to understand the RBN across the single-molecule transcriptome, not only in the context of aging and neurobiology but also for researchers to use in other biological contexts. This project could also set important first steps towards better health, healthy aging, and a decrease in avoidable neurodegeneration.

Conecta tu I+D

Entra hoy

Forgot your password?

Financing

Companies

CTIs/Universidades

Projects

researchers