Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

FUELING-TRANSPORT

Financiado

Cerrado

Deciphering the Role of Huntingtin in Energy Supply for Axonal Transport in Heal...

Deciphering the Role of Huntingtin in Energy Supply for Axonal Transport in Health and Huntington s Disease Fast axonal transport (FAT) of brain-derived neurotrophic factor (BDNF) is essential for brain function. It depends on huntingtin (HTT), the protein that when mutated causes Huntington’s disease (HD), a devastating and still incur... ver más

31/12/2024

UGA

2M€

Presupuesto del proyecto: 2M€

Líder del proyecto

UNIVERSITE GRENOBLE ALPES No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Ver 2 Participantes

Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2024-12-31

ERC-2018-ADG: ERC Advanced Grant

I+D

Cerrada hace 6 años

0% 100% 100%

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

UGA

2.37M€ | Lider

AUDENS FOOD

428.88K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

ASTRO-HD Role of astrocytes in Huntington s Disease characterization... 223K€ Cerrado

Huntingtin hPSC Unraveling huntingtin function in cortical and striatal huma... 180K€ Cerrado

SAF2008-00644 ESTUDIO DE LOS MECANISMOS MOLECULARES INVOLUCRADOS EN LA TOX... 24K€ Cerrado

HDLIPIDS2011 Role of sphingolipids in white matter dysfunction in Hunting... 250K€ Cerrado

SAF2015-65371-R ALTERACIONES EN EL PROCESAMIENTO DEL ARN EN LA ENFERMEDAD DE... 460K€ Cerrado

MECHAGGRENAMICS Mechanisms of cell dysfunction by aggregation dynamics of po... 100K€ Cerrado

Duración del proyecto: 63 meses Fecha Inicio: 2019-09-10
Fecha Fin: 2024-12-31

Líder del proyecto

UNIVERSITE GRENOBLE ALPES No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 2M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Fast axonal transport (FAT) of brain-derived neurotrophic factor (BDNF) is essential for brain function. It depends on huntingtin (HTT), the protein that when mutated causes Huntington’s disease (HD), a devastating and still incurable disorder. Unmet scientific needs: BDNF is regulated by neuronal activity and its transport requires energy. Yet we do not know if FAT of BDNF is regulated by neuronal activity and if HTT facilitates activity-dependent transport. The energy sources for FAT of BDNF and their regulation by activity remain unclear, as do the exact mechanisms of BDNF transport reduction in the HD-causing mutation. Novel hypothesis: HTT plays a key role in channeling energy by coupling energy production by glycolytic enzymes on vesicles to consumption by molecular motors for efficient axonal transport. This function is altered in HD and plays a crucial role in disease progression. By providing energy directly to vesicles, we can restore transport and slow down neurodegeneration in HD. Aim 1: investigate energy sources for axonal transport and their regulation by HTT upon high neuronal activity. Aim 2: investigate how pathogenic mutation in HTT affects response to neuronal activity and vesicles capacity to produce energy. Aim 3: restore energy sources in HD to rescue axonal transport and slow down neurodegeneration. Impact. This work will advance the understanding on how electrical activity essential for brain function regulates energy metabolism to fuel transport, specifically transport of BDNF. We will reveal essential new knowledge on the HTT function and dysfunction. This will likely lead to novel therapeutic strategies for HD. Feasibility: we have expertise in developing innovative microfluidic circuits for studying axonal transport in reconstituted neuronal circuits and in identifying new metabolic and signaling pathways. This, together with my expertise on HTT biology, puts my lab in a unique position to fulfill this ambitious programme.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores