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eNeuroMus

Financiado

Deciphering the impact of bioelectrical communication on human neuromuscular org...

Deciphering the impact of bioelectrical communication on human neuromuscular organoid maturation. Stem cells and organoids have revolutionized our ability to build tissues and organ-like structures ‘in a dish’. Organoid models of a wide range of human tissues are increasingly applied to drug and treatment development and to fu... ver más

30/04/2026

MDC

174K€

Presupuesto del proyecto: 174K€

Líder del proyecto

MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-03-13

Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023

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1 Participantes

MDC

173.85K€ | Lider

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Últimas noticias

25-11-2024: ECE En las últimas 48 horas el Organismo ECE ha otorgado 52 concesiones

25-11-2024: CMVAMADRID En las últimas 48 horas el Organismo CMVAMADRID ha otorgado 1 concesiones

25-11-2024: FUNDACION-EOI En las últimas 48 horas el Organismo FUNDACION EOI ha otorgado 6 concesiones

Duración del proyecto: 25 meses Fecha Inicio: 2024-03-13
Fecha Fin: 2026-04-30

Presupuesto del proyecto 174K€

Descripción del proyecto Stem cells and organoids have revolutionized our ability to build tissues and organ-like structures ‘in a dish’. Organoid models of a wide range of human tissues are increasingly applied to drug and treatment development and to fundamental and translational studies. However, the challenge of simultaneously growing more than one different tissues in a single functional organoid remains. Human neuromuscular organoids (NMOs) represent a landmark discovery toward building more complex and physiologically relevant human tissues in vitro. NMOs closely capture the cellular repertoire and structural and functional properties of the neuromuscular system, but, similar to other organoids, they do not reach adult tissue stages of maturation, at least in part, due to lack of connectivity and in vivo-like sensory inputs, including bioelectrical cues, essential in physiological phenomena. In a multi-disciplinary approach, the eNeuroMus project aims to test the hypothesis that delivery of brain-like input, currently excluded from NMO models, will enhance the complexity and maturation status of NMOs toward adult tissue stages. To this end, NMOs will be interfaced with conformable multielectrode arrays, based on organic conducting polymers, to expose NMOs to brain-like input via electrical stimulation and to record NMO electrophysiological activity in a growth stage-dependent manner. To decipher the effects of electrical stimulation on tissue maturation, electrophysiology assays will be combined with cutting-edge technologies, including spatial transcriptomics, optogenetics and advanced imaging. This analysis pipeline will result in a rich dataset, unravelling the long-term effects of electrical stimulation and the molecular pathways involved in the maturation of human neuromuscular organoids. Overall, the eNeuroMus project will deliver a novel and sophisticated framework for engineering the next generation of biohybrid organoids as tools for modelling human development and disease.

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